Document Detail

Sex steroids, pregnancy-associated hormones and immunity to parasitic infection.
MedLine Citation:
PMID:  15275288     Owner:  NLM     Status:  PubMed-not-MEDLINE    
A wealth of evidence has accumulated that illustrates the ability of sex-associated hormones to influence directly a variety of diverse immunological functions. Thus, it is not surprising that differences have also been noted between the sexes in their relative susceptibility to parasitic infections. Furthermore, during pregnancy, much of the observed maternal immunomodulation, essential for fetal survival, has been attributed to changes in the levels of steroid hormones. These pregnancy-induced alterations in immune function can also have profound effects on the course of parasitic infection. In this article, Craig Roberts, Abhay Satoskar and James Alexander review the immunological basis for differences in the relative susceptibilities of males, non-pregnant females and pregnant females to parasitic infection, particularly leislumaniasis and toxoplasmosis. They also discuss the role of the major sex- and pregnancy-associated hormones in mediating these effects.
C W Roberts; A Satoskar; J Alexander
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Parasitology today (Personal ed.)     Volume:  12     ISSN:  0169-4758     ISO Abbreviation:  Parasitol. Today (Regul. Ed.)     Publication Date:  1996 Oct 
Date Detail:
Created Date:  2004-07-27     Completed Date:  2005-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605563     Medline TA:  Parasitol Today     Country:  England    
Other Details:
Languages:  eng     Pagination:  382-8     Citation Subset:  -    
Division of Infectious Diseases, Michael Reese Hospital and Medical Center, 2929 South Ellis Avenue, Chicago, IL 60616-3390, USA. C.Roberts@UIC.EDU
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