Document Detail

Sex steroids and heart rate variability in patients after myocardial infarction.
MedLine Citation:
PMID:  15084213     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although the relationship between sex steroid levels and coronary artery disease (CAD) has been the subject of many studies there are still controversies concerning the role of sex steroids in CAD. In patients with CAD, especially after a myocardial infarction, there is evidence for autonomic nervous system dysfunction. However, there is no data detailing the relationship between sex steroids and cicardian autonomic activity in patients with CAD. The aim of the study was to evaluate the association between sex steroids and heart rate variability (HRV) parameters in postinfarction patients. METHODS: In 88 postinfarction men (aged 36-73, average 53 years), 24-hour Holter monitoring was performed to assess HRV parameters: SDNN, SDNNI, SDANN, rMSSD, pNN50, and levels of the following hormones were measured: testosterone, estradiol, free testosterone index, and estradiol/testosterone ratio. Univariate and multivariate regression analyses were used to investigate the relationship between HRV parameters and levels of tested hormones. RESULTS: Increased testosterone levels were associated with increased SDNN (r = 0.38, P = 0.03), increased rMSSD (r = 0.51, P = 0.002), and increased pNN50 (r = 0.45, P = 0.007). These associations remained significance after adjustment for age, ejection fraction, and other relevant clinical covariates. There was no significant association between estradiol and HRV parameters. CONCLUSION: In men with a history of myocardial infarction, higher levels of testosterone are associated with higher HRV measures of parasympathetic activity. These findings suggest that testosterone beneficially influences autonomic regulation of the heart.
Jerzy Krzysztof Wranicz; Marcin Rosiak; Iwona Cygankiewicz; Piotr Kula; Krzysztof Kula; Wojciech Zareba
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc     Volume:  9     ISSN:  1082-720X     ISO Abbreviation:  Ann Noninvasive Electrocardiol     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-15     Completed Date:  2004-11-16     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  9607443     Medline TA:  Ann Noninvasive Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  156-61     Citation Subset:  IM    
Department of Cardiology, Medical University of Lodz, Lodz, Poland.
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MeSH Terms
Androgens / metabolism
Biological Markers / blood
Coronary Artery Disease / blood,  physiopathology
Electrocardiography, Ambulatory
Estradiol / metabolism
Heart Rate / drug effects,  physiology*
Middle Aged
Multivariate Analysis
Myocardial Infarction / blood*,  physiopathology*
Statistics as Topic
Steroids / metabolism*
Stroke Volume / physiology
Testosterone / metabolism
Reg. No./Substance:
0/Androgens; 0/Biological Markers; 0/Steroids; 50-28-2/Estradiol; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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