Document Detail

Sex, stem cells and tumors in the Drosophila ovary.
MedLine Citation:
PMID:  23208193     Owner:  NLM     Status:  MEDLINE    
The Drosophila Sex-lethal (Sxl) gene encodes a female-specific RNA binding protein that in somatic cells globally regulates all aspects of female-specific development and behavior. Sxl also has a critical, but less well understood, role in female germ cells. Germ cells without Sxl protein can adopt a stem cell fate when housed in a normal ovary, but fail to successfully execute the self-renewal differentiation fate switch. The failure to differentiate is accompanied by the inappropriate expression of a set of male specific markers, continued proliferation, and formation of a tumor. The findings in Chau et al., (2012) identify the germline stem cell maintenance factor nanos as one of its target genes, and suggest that Sxl enables the switch from germline stem cell to committed daughter cell by posttranscriptional downregulation of nanos expression. These studies provide the basis for a new model in which Sxl directly couples sexual identity with the self-renewal differentiation decision and raises several interesting questions about the genesis of the tumor phenotype.
Helen K Salz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-03
Journal Detail:
Title:  Fly     Volume:  7     ISSN:  1933-6942     ISO Abbreviation:  Fly (Austin)     Publication Date:    2013 Jan-Mar
Date Detail:
Created Date:  2013-05-03     Completed Date:  2013-12-10     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101470897     Medline TA:  Fly (Austin)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-7     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Cell Lineage
Drosophila / cytology,  physiology*
Drosophila Proteins / metabolism,  physiology*
Ovary / cytology*
RNA-Binding Proteins / metabolism,  physiology*
Signal Transduction
Stem Cells / cytology,  metabolism,  physiology*
Grant Support
Reg. No./Substance:
0/Drosophila Proteins; 0/RNA-Binding Proteins; 0/Sxl protein, Drosophila; 142661-95-8/nanos protein, Drosophila

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