Document Detail


Sex-specific hemodynamic and non-hemodynamic determinants of aortic root size in hypertensive subjects with left ventricular hypertrophy.
MedLine Citation:
PMID:  19713970     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aortic root (AoR) dilatation is more frequently observed in hypertensive individuals and is independently associated with left ventricular (LV) hypertrophy. Although the LV structure has sex-specific predictors, it remains unknown whether there are gender-related differences in the determinants of AoR size. We carried out a cross-sectional analysis of clinical, laboratory, anthropometric, funduscopic and echocardiographic features of 438 hypertensive patients with LV hypertrophy (266 women and 172 men). Women with enlarged AoR had higher cardiac output (P=0.0004), decreased peripheral vascular resistance (P=0.009), higher prevalence of mild aortic regurgitation (P=0.02) and increased waist circumference (P=0.04), whereas AoR-dilated men presented with a higher prevalence of concentric LV hypertrophy (P=0.0008) and mild aortic regurgitation (P=0.005) and increased log C-reactive protein levels (P=0.02), compared with sex-matched normal AoR subjects. In women, AoR dilatation associated with cardiac output, mild aortic regurgitation and waist circumference in a multivariate model including age, body surface area, height, homeostasis model assessment index, LV mass index, diastolic blood pressure, menopause status and use of antihypertensive medications as independent variables. Conversely, AoR dilatation associated with LV relative wall thickness, log C-reactive protein and mild aortic regurgitation without contributions from diastolic blood pressure, height, body surface area, LV mass index, peripheral vascular resistance and antihypertensive medications in men. Taken together, these results suggest that both volume overload and abdominal obesity are related to AoR dilatation in hypertensive women, whereas AoR enlargement is associated more with inflammatory and myocardial growth-related parameters in hypertensive men with LV hypertrophy.
Authors:
Jos?? A A Cipolli; Felipe A S Souza; Maria C S Ferreira-Sae; Jos?? A Pio-Magalh??es; Eug??nio S Figueiredo; Vanessa G Vidotti; Jos?? R Matos-Souza; Kleber G Franchini; Wilson Nadruz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-28
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  32     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-05     Completed Date:  2010-01-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  956-61     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, School of Medicine, University of Campinas, Campinas, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta / physiopathology,  ultrasonography*
Aortic Valve Insufficiency / physiopathology
Blood Pressure / physiology
Electrocardiography
Female
Hemodynamics / physiology*
Homeostasis
Humans
Hypertension / physiopathology*,  ultrasonography*
Hypertrophy, Left Ventricular / physiopathology*,  ultrasonography*
Male
Middle Aged
Myocardium / pathology
Phenotype
Regression Analysis
Sex Characteristics
Stroke Volume / physiology
Vascular Resistance / physiology
Vasodilation / physiology
Waist Circumference

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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