| Sex-specific and exercise-acquired cardioprotection is abolished by sarcolemmal KATP channel blockade in the rat heart. | |
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MedLine Citation:
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PMID: 17237239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was conducted to determine whether the infarct sparing effect of short-term exercise is dependent on the operation of the myocardial sarcolemmal ATP-sensitive K(+) (K(ATP)) channel. Adult male and female Sprague-Dawley rats were exercised on a motorized treadmill for 5 days. Twenty-four hours following the training or sedentary period, hearts were isolated and exposed to 1 h of regional ischemia followed by 2 h of reperfusion on a modified Langendorf apparatus in the presence or absence of the sarcolemmal K(ATP) channel antagonist HMR-1098 (30 microM). Following the ischemia-reperfusion protocol, infarct size was determined as a percentage of the total ischemic zone at risk (ZAR). Short-term exercise reduced infarct size by 24% in males (32 +/- 2% of ZAR; P < 0.01) and by 18% in females (26 +/- 2% of ZAR; P < 0.05). Sarcolemmal K(ATP) channel blockade abolished the training-induced cardioprotection in both males and females, increasing infarct size to 43 +/- 3% and 52 +/- 4% of ZAR, respectively. In the absence of HMR-1098, infarct size was significantly lower in sedentary females than in males (33 +/- 4% vs. 42 +/- 2% of ZAR, respectively; P < 0.01). However, the presence of HMR-1098 abolished this sex difference, increasing infarct size by 58% in the sedentary females (P < 0.01) but having no effect on infarct size in sedentary males. This study demonstrates that the sex-specific and exercise-acquired resistance to myocardial ischemia-reperfusion injury is dependent on sarcolemmal K(ATP) activity during ischemia. |
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Authors:
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Adam J Chicco; Micah S Johnson; Casey J Armstrong; Joshua M Lynch; Ryan T Gardner; Geoff S Fasen; Cody P Gillenwater; Russell L Moore |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-01-19 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 292 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-09 Completed Date: 2007-06-27 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H2432-7 Citation Subset: IM |
Affiliation:
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Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzamides / pharmacology* Exercise Therapy / methods* Female Heart / drug effects, physiopathology* Male Myocardial Reperfusion Injury / physiopathology*, therapy* Physical Conditioning, Animal / methods* Potassium Channels / drug effects, metabolism* Rats Rats, Sprague-Dawley Sex Factors Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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HL 72790/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzamides; 0/HMR 1098; 0/Potassium Channels; 0/mitochondrial K(ATP) channel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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