| Sex-specific effects of ACE I/D and AGT-M235T on pulse pressure: the HyperGEN Study. | |
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MedLine Citation:
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PMID: 17492314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence shows that an elevated pulse pressure (PP) may lead to an increased risk of cardiovascular morbidity and mortality. There is also evidence that PP is a sexually dimorphic trait, and that genetic factors influence inter-individual variation in PP. The aim of this project was to assess the genotype-by-sex interaction on PP in a sample of mostly hypertensive African American and White participants using candidate genes involved in the renin-angiotensin-aldosterone system. Subjects were participants in the HyperGEN Study, including men (43%) and women (57%) over the age of 55 years (mean age = 65). Candidate gene polymorphisms used were ACE insertion/deletion (1,789 subjects genotyped) and AGT-M235T (1,800 subjects genotyped). We employed linear regression methods to assess the genotype-by-sex interaction. For ACE, genotype-by-sex interaction on PP was detected (P = 0.04): the "D/D" genotype predicted a 2.2 mmHg higher pulse pressure among women, but a 1.2 mmHg lower PP among men, compared to those with an "I" allele, after adjusting for age, weight, height, ethnicity, and antihypertension medication use. A similar interaction was found for systolic blood pressure. The genotype-by-sex interaction was consistent across ethnicity. The interaction was evident among those on antihypertensive medications (P = 0.05), but not among those not taking such medications (P = 0.55). In our analysis of AGT, no evidence of a genotype-by-sex interaction affecting PP, SBP, or DBP was detected. This evidence for a genotype-by-sex interaction helps our understanding of the complex genetic underpinnings of blood pressure phenotypes. |
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Authors:
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Amy I Lynch; Donna K Arnett; James S Pankow; Michael B Miller; Kari E North; John H Eckfeldt; Steven C Hunt; Dabeeru C Rao; Luc Djoussé |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-05-10 |
Journal Detail:
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Title: Human genetics Volume: 122 ISSN: 1432-1203 ISO Abbreviation: Hum. Genet. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-04 Completed Date: 2008-04-30 Revised Date: 2008-06-27 |
Medline Journal Info:
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Nlm Unique ID: 7613873 Medline TA: Hum Genet Country: Germany |
Other Details:
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Languages: eng Pagination: 33-40 Citation Subset: IM |
Affiliation:
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Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Angiotensinogen / genetics* Antihypertensive Agents / therapeutic use Blood Pressure / genetics* Epidemiologic Studies Female Gene Frequency Genotype Humans Hypertension / drug therapy, epidemiology, ethnology, genetics INDEL Mutation* / physiology Male Middle Aged Peptidyl-Dipeptidase A / genetics* Polymorphism, Single Nucleotide* / physiology Sex Characteristics* |
| Grant Support | |
ID/Acronym/Agency:
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HL 54472/HL/NHLBI NIH HHS; HL007972/HL/NHLBI NIH HHS; HL54471/HL/NHLBI NIH HHS; HL54473/HL/NHLBI NIH HHS; HL54495/HL/NHLBI NIH HHS; HL54496/HL/NHLBI NIH HHS; HL54497/HL/NHLBI NIH HHS; HL54509/HL/NHLBI NIH HHS; HL54515/HL/NHLBI NIH HHS; HL55673/HL/NHLBI NIH HHS; M10RR0047-34/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 11002-13-4/Angiotensinogen; EC 3.4.15.1/ACE protein, human; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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