| Sex-specific effect of aging on submaximal leg exercise hemodynamics in middle-aged and older adults. | |
| | |
MedLine Citation:
|
PMID: 21153657 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The purpose of the study was to examine predictors of the leg hemodynamic response to exercise in middle- and older-aged men and women. Femoral artery blood flow (FBF), mean arterial pressure (MAP), and femoral vascular conductance (FVC, calculated as the quotient of FBF and MAP) were measured at rest and during 5 min of single knee-extensor exercise at ~10 W workload in healthy men (n = 31) and women (n = 32) (age 40-72 years). Age, menopausal status, maximal quadriceps strength, blood lipids, vitamin D levels, maximal oxygen uptake (VO(2max)), physical activity, blood pressure, estimated quadriceps muscle mass, and body mass index (BMI) were also assessed. The effect of age on FBF and FVC was negative and significant in men (r = -0.44 and -0.42 and p = 0.01 and 0.02, respectively) but was abolished by normalization to estimated quadriceps muscle (p = 0.18 and 0.73, respectively). There was no effect of age on leg hemodynamic responses to exercise in women (alone or normalized to quadriceps muscle), but menopausal status was a significant predictor of FVC and normalized FVC (p = 0.04 and 0.02, respectively). The multivariate model for exercising FVC in men (in order of strongest to weakest predictors) included quadriceps strength, BMI, resting FVC, age, and high-density lipoprotein cholesterol. The multivariate model for exercising FVC in women included quadriceps mass, systolic blood pressure, vitamin D, age, VO(2max), waist circumference, and physical activity score. These findings suggest that factors besides chronological age mediate exercising leg hemodynamics in middle-aged to older adults and that these factors are sex-specific. |
| | |
Authors:
|
Beth Parker; Jeffrey Capizzi; Amanda Augeri; Adam Grimaldi; David Proctor; Paul Thompson |
Related Documents
:
|
11774067 - Body composition and cardiorespiratory fitness indicators in prepubescent boys and girls. 1861487 - Physical activity and lean body mass loss following coronary artery bypass graft surgery. 192607 - sensitivity to adrenocorticotropic hormone during adaptation to increased muscle activity 21940307 - Rehabilitation exercise on the quality of life in anal sphincter-preserving surgery. 4028197 - Response of interphasic nucleoli to hypoxia in root meristems. 21561297 - Effectiveness of physical therapy for improving gait and balance in individuals with tr... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-14 |
Journal Detail:
|
Title: European journal of applied physiology Volume: - ISSN: 1439-6327 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Henry Low Heart Center, Department of Cardiology, Hartford Hospital, Hartford, CT, 06102, USA, bparker03@harthosp.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Distribution study of peplomycin in rat kidney revealed by immunocytochemistry using monoclonal anti...
Next Document: The effect of muscle length on force depression after active shortening in soleus muscle of mice.