| Sex-specific association of anthropometric measures of body composition with arterial stiffness in a healthy population. | |
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MedLine Citation:
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PMID: 22293879 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Anthropometric measures of body composition and arterial stiffness are commonly used as indicators of cardiovascular risk. Little is known, however, about the association of the anthropometric measures with arterial stiffness, especially in a healthy, generally non-obese population.<br /> Material/Methods: In a sample of 352 healthy subjects (200 premenopausal women), 3 arterial stiffness indices were analyzed (pulse wave velocity, augmentation index and central systolic blood pressure) in relation to 5 anthropometric measures of body composition (body mass index - BMI, body fat percentage by skinfold measurements -%BF, waist circumference - WC, waist-hip ratio - WHpR, and waist-height ratio - WHtR). Data were analyzed using correlation and regression analyses, with adjustment for the following confounders: age, blood pressures, height, heart rate, blood lipids and smoking.<br /> Results: Most correlations between anthropometric measures and arterial stiffness indices were significant and positive in both sex groups (r=0.14-0.40, P<0.05). After adjustment for confounding effects, BMI, WC and WHtR remained significant (but inverse) predictors of arterial stiffness (β from -0.06 to -0.16; P<0.05) in the females, while in the males BMI was the only measure inversely predicting arterial stiffness (β from -0.09 to -0.13; P<0.05).<br /> Conclusions: Measures of body composition are weak and inverse predictors of arterial stiffness and their influence is sex-dependent. BMI, WC and WHtR were key predictors of arterial stiffness in the females, while BMI was the principal predictor in the males. The associations of anthropometric measures with arterial stiffness are strongly and differently confounded by various factors that have to be taken into account when explaining results of similar studies.<br /> |
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Authors:
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Danijela Budimir; Ana Jeroncic; Grgo Gunjaca; Igor Rudan; Ozren Polasek; Mladen Boban |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 18 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: CR65-71 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, University of Split School of Medicine, Split, Croatia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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