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Sex and speciation: the paradox that non-recombining DNA promotes recombination.
MedLine Citation:
PMID:  23136582     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The benefits of sexual reproduction that outweigh its costs have long puzzled biologists. Increased genetic diversity generated by new allelic combinations, as enhanced by recombination during meiosis, is considered to be a primary benefit of sex. Sex-determining systems have evolved independently on numerous occasions. One of the most familiar is the use of sex chromosomes in vertebrates. Other eukaryotic groups also use sex chromosomes or smaller sex-determining regions within their chromosomes, such as the mating type loci in the fungi. In these organisms, sexual reproduction and its associated meiotic recombination is controlled by regions of the genome that are themselves blocked in recombination. Non-recombining DNA that is essential for recombination presents a paradox. One hypothesis is that sex-determination requires or leads to highly diverse alleles, establishing this block in recombination. A second hypothesis to account for the common occurrence of these types of sex-determining systems is that they combine mechanisms for recombination suppression and reproductive isolation, thereby promoting the evolution of new species. The fungal kingdom represents the ideal eukaryotic lineage to elucidate the functions of non-recombining regions in sex-determination and speciation.
Authors:
Alexander Idnurm
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-12
Journal Detail:
Title:  Fungal biology reviews     Volume:  25     ISSN:  1878-0253     ISO Abbreviation:  Fungal Biol Rev     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101320029     Medline TA:  Fungal Biol Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  121-127     Citation Subset:  -    
Affiliation:
School of Biological Sciences, University of Missouri-Kansas City, MO 64110, USA.
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