Document Detail

Sex reversal in XY mice caused by dominant mutation on chromosome 17.
MedLine Citation:
PMID:  6855886     Owner:  NLM     Status:  MEDLINE    
A Y-linked gene(s) is undoubtedly a prerequisite for testicular development in mammals. However, exceptional cases suggest that the mere presence of the Y chromosome or the Y-linked testis-determining gene does not totally control the fate of the bipotential gonad. For example, in the mouse, a major as yet unmapped autosomal locus is necessary for normal testicular development and at least one additional autosomal locus is implicated. We present here a third autosomal sex-determining locus. This dominantly inherited trait, tentatively named T-associated sex reversal (gene symbol Tas), is closely linked to or a part of the T/t complex on chromosome 17 of the mouse. Gonads of chromosomally XY individuals who inherit Tas on the C57BL/6J inbred strain background differentiate as ovaries or ovotestes.
L L Washburn; E M Eicher
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature     Volume:  303     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-07-08     Completed Date:  1983-07-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  338-40     Citation Subset:  IM    
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MeSH Terms
Chromosome Mapping
Genes, Dominant
Ovary / embryology
Sex Determination (Analysis)*
Testis / embryology
Grant Support

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