| Sex-related splenocyte function in a murine model of allergic asthma. | |
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MedLine Citation:
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PMID: 18498415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The prevalence and severity of asthma are higher among boys than girls, but the ratios are reversed after puberty. These observations strongly suggest that sex hormones have a role in the pathogenesis of the disease. However, the mechanisms underlying the gender differences in asthma are not fully understood. OBJECTIVE: The aim of this study was to investigate sex differences in allergic inflammation in terms of immune function. METHODS: Male and female C57BL/6 mice were sensitized and challenged with ovalbumin (OVA). OVA-specific IgE in serum and airway inflammation were compared between sexes. Splenocytes from OVA-sensitized male or female donor mice were transferred to male or female naïve recipient mice. Subsequently, the recipient mice were challenged, followed by the evaluation of OVA-specific IgE and airway inflammation. Cytokines secreted from splenocytes of the sensitized mice were measured. RESULTS: The levels of OVA-specific IgE and the allergen-induced airway inflammation were higher in female than in the male mice. The contents of T-helper type 2 (Th2) cytokines, IL-4, IL-5 and IL-13, in the bronchoalveolar lavage fluid from female mice were higher than those from male mice. The airway inflammation in female recipients transferred with splenocytes from female donors was more severe than that in any other combination of recipients and donors. Splenocytes from the sensitized female mice produced more of the Th2 cytokine, IL-5, than those from the sensitized male mice upon stimulation with OVA. CONCLUSION: Our findings suggest that the sex difference in allergic airway inflammation may be attributable to the sex difference in not only the hormonal environment but also in the immune cells themselves. |
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Authors:
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K Okuyama; K Wada; J Chihara; M Takayanagi; I Ohno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-21 |
Journal Detail:
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Title: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology Volume: 38 ISSN: 1365-2222 ISO Abbreviation: Clin. Exp. Allergy Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-08-11 Completed Date: 2008-10-27 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8906443 Medline TA: Clin Exp Allergy Country: England |
Other Details:
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Languages: eng Pagination: 1212-9 Citation Subset: IM |
Affiliation:
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Department of Pathophysiology, Tohoku Pharmaceutical University, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asthma / immunology*, metabolism Bronchoalveolar Lavage Fluid / cytology, immunology* Eosinophils / immunology, metabolism Female Immunoglobulin E / blood* Inflammation / immunology, metabolism Interferon-gamma / immunology, metabolism Interleukin-13 / biosynthesis, immunology Interleukin-4 / biosynthesis, immunology Interleukin-5 / biosynthesis, immunology Male Mice Mice, Inbred C57BL Ovalbumin / immunology* Sex Characteristics* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-13; 0/Interleukin-5; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E; 82115-62-6/Interferon-gamma; 9006-59-1/Ovalbumin |
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