Document Detail


Sex-related pharmacokinetic and pharmacodynamic variations of lisinopril.
MedLine Citation:
PMID:  9044242     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to determine whether or not the pharmacokinetic and hemodynamic response to a 20 mg single oral dose of lisinopril was sex-dependent. Thirty-two young healthy volunteers (16 males and 16 females) were included in the trial. Blood samples to assess lisinopril plasma concentrations, determined indirectly by inhibition of the angiotensin converting enzyme (ACE) and hemodynamic variables, were obtained before and at different times following drug intake. No significant differences in pharmacokinetic parameters were observed between males and females. An hypotensive response was obtained between 2 and 10 h for systolic blood pressure and between 2 and 24 h for diastolic blood pressure. Again, no significant sex-related differences were noted. Lisinopril was well tolerated.
Authors:
D Sáenz-Campos; M C Bayés; E Masana; S Martín; M Barbanoj; F Jané
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  18     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1997-06-17     Completed Date:  1997-06-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Clinical Toxicology, Faculty of Medicine, University of Costa Rica.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Angiotensin-Converting Enzyme Inhibitors / pharmacokinetics*,  pharmacology
Blood Pressure / drug effects
Female
Humans
Lisinopril / pharmacokinetics*,  pharmacology
Male
Sex Factors
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 83915-83-7/Lisinopril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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