| Sex-related pharmacokinetic and pharmacodynamic variations of lisinopril. | |
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MedLine Citation:
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PMID: 9044242 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to determine whether or not the pharmacokinetic and hemodynamic response to a 20 mg single oral dose of lisinopril was sex-dependent. Thirty-two young healthy volunteers (16 males and 16 females) were included in the trial. Blood samples to assess lisinopril plasma concentrations, determined indirectly by inhibition of the angiotensin converting enzyme (ACE) and hemodynamic variables, were obtained before and at different times following drug intake. No significant differences in pharmacokinetic parameters were observed between males and females. An hypotensive response was obtained between 2 and 10 h for systolic blood pressure and between 2 and 24 h for diastolic blood pressure. Again, no significant sex-related differences were noted. Lisinopril was well tolerated. |
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Authors:
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D Sáenz-Campos; M C Bayés; E Masana; S Martín; M Barbanoj; F Jané |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods and findings in experimental and clinical pharmacology Volume: 18 ISSN: 0379-0355 ISO Abbreviation: Methods Find Exp Clin Pharmacol Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1997-06-17 Completed Date: 1997-06-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7909595 Medline TA: Methods Find Exp Clin Pharmacol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 533-8 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Clinical Toxicology, Faculty of Medicine, University of Costa Rica. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Angiotensin-Converting Enzyme Inhibitors / pharmacokinetics*, pharmacology Blood Pressure / drug effects Female Humans Lisinopril / pharmacokinetics*, pharmacology Male Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 83915-83-7/Lisinopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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