Document Detail

Sex-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydro-pyridine treatment may be related to differences in monoamine oxidase B.
MedLine Citation:
PMID:  7830954     Owner:  NLM     Status:  MEDLINE    
Effects of the parkinsonism inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on striatal dopamine metabolism and the influence of sex on the recovery were investigated in adult (2-month-old) male and female C57/BL mice. We present here evidence that MPTP treatment (2 doses of 30 mg/kg i.p., each at 24 h interval) produced a similar reduction (-65% to -70%) of striatal dopamine in both sexes 24 h after the last injection of MPTP, and a greater loss of the metabolites in the female group. In contrast to the partial recovery observed in the male group, an increased dopamine loss occurred in the female group within 10 days following the last injection of MPTP. This impairment in recovery appears to be different to the one already observed in aged (24-month-old) male mice treated in similar conditions. As the neurotoxic effects of MPTP depend on its conversion to the 1-methyl-4-phenylpyridinium ion (MPP+) by monoamine oxidase B (MAO B), the presence of a different peripheral or central MAO B type in female mice could be in part responsible for these sex related effects. To investigate this possibility, MAO A and B activities were characterized in liver and brain of adult female control mice during the different steps of the oestrous cycle and compared to those of adult control male mice. Significant differences in MAO A and MAO B activities could be detected during the oestrous cycle and between the adult male and female groups. It is concluded that MAO B may be involved in the sex related effects of MPTP.
M Unzeta; S Baron; V Perez; S Ambrosio; N Mahy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  176     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-02-21     Completed Date:  1995-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  235-8     Citation Subset:  IM    
Departamento Bioquímica i Biologia Molecular, Facultad de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
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MeSH Terms
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / metabolism,  pharmacology*
1-Methyl-4-phenylpyridinium / metabolism
3,4-Dihydroxyphenylacetic Acid / metabolism
Dopamine / metabolism
Estrus / physiology
Homovanillic Acid / metabolism
Mice, Inbred C57BL
Monoamine Oxidase / metabolism*
Neostriatum / enzymology,  metabolism
Sex Characteristics
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 306-08-1/Homovanillic Acid; 48134-75-4/1-Methyl-4-phenylpyridinium; EC Oxidase

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