Document Detail

Sex ratio and pregnancy complications according to mode of conception in women with polycystic ovary syndrome.
MedLine Citation:
PMID:  19900142     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate pregnancy complications and offspring sex ratio according to mode of conception in women with polycystic ovary syndrome (PCOS). DESIGN: Retrospective, descriptive study. SETTING: Tertiary, university hospital. POPULATION: A total of 176 women with PCOS diagnosed according to the Rotterdam criteria. METHODS: Women with PCOS who have participated in one or more clinical studies were invited to answer a questionnaire on the mode of conception, pregnancy complications, gestational length and offspring gender. A total of 139 women responded. Data were quality checked against hospital files. MAIN OUTCOME MEASURES: Fertility, mode of conception, offspring gender and pregnancy complications. RESULTS: More than half (54%) of the singleton pregnancies were conceived spontaneously. More complications were seen in pregnancies achieved while using metformin than without (p = 0.02). Compared to spontaneous conception, more boys than girls were born in singleton pregnancies after in vitro fertilization/intracytoplasmatic sperm injection treatment (p = 0.004). CONCLUSIONS: In women with PCOS the mode of conception may influence both the rate of pregnancy complications and the offspring sex ratio.
Eszter Vanky; Bjørn Backe; Sven M Carlsen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  88     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-10     Completed Date:  2009-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  1261-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
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MeSH Terms
Polycystic Ovary Syndrome / physiopathology*
Pregnancy Complications*
Regression Analysis
Retrospective Studies
Sex Ratio*
Sperm Injections, Intracytoplasmic*
Young Adult

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