Document Detail


Sex moderates associations between prenatal glucocorticoid exposure and human fetal neurological development.
MedLine Citation:
PMID:  22925508     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Maternal cortisol levels (at 15, 19, 25, 31 and 37 weeks' gestation) and fetal movement response to vibroacoustic stimulation (VAS; at 25, 31 and 37 weeks) were assessed in 190 mother-fetus pairs. Fetuses showed a response to the VAS at 25 weeks and there was evidence of increasing maturation in the response at 31 and 37 weeks. Early elevations in cortisol predicted a failure to respond to the VAS at 25 weeks and later elevations in cortisol were associated with a larger response among fetuses when assessed near term. The associations between cortisol and VAS emerged earlier and were more apparent among female fetuses than among the males. The findings provide support for the role of prenatal glucocorticoids in shaping human fetal CNS development.
Authors:
Laura M Glynn; Curt A Sandman
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Publication Detail:
Type:  Journal Article     Date:  2012-06-27
Journal Detail:
Title:  Developmental science     Volume:  15     ISSN:  1467-7687     ISO Abbreviation:  Dev Sci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814574     Medline TA:  Dev Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  601-10     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Crean School of Health and Life Sciences, Chapman University, USA  Department of Psychiatry, University of California, Irvine, USA.
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