Document Detail

Sex may modify the effects of macronutrient intake on metabolic syndrome and insulin resistance in American Indians: the strong heart study.
MedLine Citation:
PMID:  18442502     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Diet has been related to several characteristics of metabolic syndrome (MSDR) and insulin resistance, which carry an increased risk for diabetes and heart disease.
OBJECTIVE: To examine the cross-sectional association between macronutrient intake, sex, and MSDR and insulin resistance in American Indians without diabetes.
DESIGN: Dietary intake, MSDR, and insulin resistance (estimated by homeostasis model assessment) were assessed.
SUBJECTS/SETTING: Data were analyzed from participants with complete dietary data (n=1,516 for MSDR, n=1,458 for insulin resistance) from the second examination (1993-1995) of the Strong Heart Study, a longitudinal, population-based study of cardiovascular disease and its risk factors in American Indians.
STATISTICAL ANALYSES: Logistic regression and analysis of covariance were used to study associations among tertiles of macronutrient intake and MSDR and homeostasis model assessment scores.
RESULTS: Polyunsaturated fatty acid intake was associated with less MSDR and lower homeostasis model assessment scores in women (odds ratio 0.69 and 95% confidence interval 0.50 to 0.96 for MSDR in the third tertile) but not men. Higher simple carbohydrate intake was associated with more MSDR in men (odds ratio 1.72 and 95% confidence interval 1.10 to 2.69 in the third tertile) but not women.
CONCLUSIONS: Polyunsaturated fatty acid and simple carbohydrates may be associated with MSDR and insulin resistance in American Indians and sex may modify the association between dietary intake and MS and insulin resistance in this population. Further studies should focus on the longitudinal association between dietary intake and incidence of MSDR and insulin resistance and the role of sex in this relationship in American Indians and other populations.
Sigal Eilat-Adar; Jiaqiong Xu; Uri Goldbourt; Ellie Zephier; Barbara V Howard; Helaine E Resnick
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of the American Dietetic Association     Volume:  108     ISSN:  0002-8223     ISO Abbreviation:  J Am Diet Assoc     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-29     Completed Date:  2008-06-11     Revised Date:  2014-04-23    
Medline Journal Info:
Nlm Unique ID:  7503061     Medline TA:  J Am Diet Assoc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  794-802     Citation Subset:  AIM; IM    
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MeSH Terms
Analysis of Variance
Body Mass Index
Cohort Studies
Confidence Intervals
Cross-Sectional Studies
Dietary Carbohydrates / administration & dosage*,  metabolism
Dietary Fats / administration & dosage*,  metabolism
Dietary Fats, Unsaturated / administration & dosage,  metabolism
Dietary Fiber / administration & dosage
Dietary Proteins / administration & dosage
Food Habits
Indians, North American / statistics & numerical data*
Insulin Resistance*
Logistic Models
Metabolic Syndrome X / epidemiology*
Middle Aged
Odds Ratio
Risk Factors
Sex Factors
United States
Grant Support
U01 HL041642/HL/NHLBI NIH HHS; U01 HL041642-12/HL/NHLBI NIH HHS; U01 HL041642-13/HL/NHLBI NIH HHS; U01 HL041642-13S1/HL/NHLBI NIH HHS; U01 HL041642-14/HL/NHLBI NIH HHS; U01 HL041642-15/HL/NHLBI NIH HHS; U01 HL041642-15S1/HL/NHLBI NIH HHS; U01 HL041642-16/HL/NHLBI NIH HHS; U01 HL041642-17/HL/NHLBI NIH HHS; U01 HL041642-17S1/HL/NHLBI NIH HHS; U01 HL041642-18A1/HL/NHLBI NIH HHS; U01 HL041642-19/HL/NHLBI NIH HHS; U01 HL041642-19S1/HL/NHLBI NIH HHS; U01 HL041642-20/HL/NHLBI NIH HHS; U01HL-41642/HL/NHLBI NIH HHS; U01HL-41652/HL/NHLBI NIH HHS; U01HL-41654/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Dietary Proteins

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