Document Detail

Sex hormones and sarcopenia in older persons.
MedLine Citation:
PMID:  23222704     Owner:  NLM     Status:  In-Data-Review    
PURPOSE OF REVIEW: Sarcopenia is a geriatric syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability, poor quality of life, and death. Sarcopenia is a multifactorial process involving the decline of androgens, including dehydroepiandrosterone sulphate (DHEAS) and testosterone. The aim of this review is to highlight the effects of DHEAS and testosterone treatment to counteract sarcopenia, especially in older men.
RECENT FINDINGS: DHEAS and, more importantly, testosterone treatment are associated with increased muscle mass, whereas the effects on muscle function and physical performance are less clear. The results of recent randomized placebo controlled trials with DHEAS in older men and women and testosterone in men with mobility limitation are discussed. The novel current and future scenarios to attenuate the detrimental effects and to optimize the efficacy of sex hormone treatment are also addressed.
SUMMARY: DHEAS and testosterone are important options in the armamentarium of sarcopenia treatment in older men. Future studies are needed to address new approaches by using selective compounds, targeting the correct form and dosage, tailoring the correct patient to treat, and taking into account the multifactorial origin and the new definition of sarcopenia.
Marcello Maggio; Fulvio Lauretani; Gian Paolo Ceda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  16     ISSN:  1473-6519     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  3-13     Citation Subset:  IM    
aDepartment of Clinical and Experimental Medicine, Section of Geriatrics, University of Parma bGeriatric Rehabilitation Department, University-Hospital of Parma, Parma, Italy.
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