Document Detail

Sex hormones in psychotic men.
MedLine Citation:
PMID:  15358449     Owner:  NLM     Status:  MEDLINE    
For women at risk to develop schizophrenia, estradiol has been postulated to constitute a protective factor. Women suffering from psychotic disorders have accordingly been found to exhibit lower estradiol levels than controls. Our aim was to study gonadal function in psychotic men to determine the gender specificity of these observations, as available data in men are more scarce and conflicting and largely disregarded estradiol. Serum hormone levels were examined in 34 men admitted consecutively for an acute exacerbation or first onset of schizophrenia in a blinded prospective design. Subjects with current affective disorder including manic episode, concomitant substance abuse or severe medical illness were excluded. A control group of 34 healthy male blood donors was recruited. As compared to matched controls, acutely admitted men suffering from schizophrenia exhibited significantly lower serum levels of estradiol, oestrone, testosterone and free testosterone. Although results have to be regarded as preliminary, acute exacerbation of schizophrenia in men seems to be associated with low serum oestrogen and androgen levels. The oestrogen hypothesis postulating a protective action of estradiol concerning schizophrenia for women might well be valid for both genders. However, future research is needed before clinical applications are justified.
Thomas J Huber; Christian Tettenborn; Eckhard Leifke; Hinderk M Emrich
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  30     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-09-10     Completed Date:  2004-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  111-4     Citation Subset:  IM    
Department of Clinical Psychiatry and Psychotherapy, Medical School of Hannover, Carl-Neuberg-Strasse 1, D-30623 Hannover, Germany.
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MeSH Terms
Antipsychotic Agents / adverse effects
Estradiol / blood
Estrone / blood
Gonadal Steroid Hormones / blood*
Prolactin / blood
Prospective Studies
Psychiatric Status Rating Scales
Psychotic Disorders / blood*
Schizophrenia / blood
Testosterone / blood
Reg. No./Substance:
0/Antipsychotic Agents; 0/Gonadal Steroid Hormones; 50-28-2/Estradiol; 53-16-7/Estrone; 58-22-0/Testosterone; 9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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