| Sex hormones and autoimmune rheumatic disorders. | |
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MedLine Citation:
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PMID: 2786646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has now been recognized that there are complex interactions between the gonadal endocrine and the immune systems. The action of sex hormones on the immune system has important physiological and pathological consequences. The preponderance in women of autoimmune diseases in humans and in experimental animals has a basis in sex hormones. Hypoandrogenic/hyperestrogenic states are thought to contribute to the disease process. This article presents evidence for the action of sex hormones in various experimental animal models of autoimmune diseases and discusses several mechanisms of sex hormone action on the immune system. These mechanisms remain complex and it is to be hoped that the recent advances in immunology, endocrinology, pharmacology, and molecular biology will enable the description and clarification of these mechanisms of action. |
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Authors:
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S Ansar Ahmed; N Talal |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Scandinavian journal of rheumatology Volume: 18 ISSN: 0300-9742 ISO Abbreviation: Scand. J. Rheumatol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-07-18 Completed Date: 1989-07-18 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0321213 Medline TA: Scand J Rheumatol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 69-76 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Texas Health Science Center, San Antonio. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoantibodies / analysis Autoimmune Diseases / immunology* B-Lymphocytes / immunology Bromelains / immunology Erythrocytes / immunology Estrogens / immunology* Female Male Mice Orchiectomy Receptors, Androgen* Receptors, Estrogen / immunology Receptors, Steroid / immunology T-Lymphocytes / immunology Testosterone / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Estrogens; 0/Receptors, Androgen; 0/Receptors, Estrogen; 0/Receptors, Steroid; 58-22-0/Testosterone; 9001-00-7/Bromelains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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