Document Detail


Sex hormone-binding globulin and corticosteroid-binding globulin mRNA levels in infertile women with luteal phase deficiency.
MedLine Citation:
PMID:  8540288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to investigate the biological significance in intracellular expression of sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) mRNA in uterine endometrium with luteal phase deficiency (designated as out-of-phase endometrium or low serum progesterone level). The levels of such mRNAs were measured by the quantitative reverse transcription-polymerase chain reaction. Under the normal serum 17 beta-estradiol and progesterone levels in the mid-luteal phase, the levels of SHBG and CBG mRNAs in the out-of-phase endometria were not significantly different from those in the normal endometria. On the other hand, SHBG and CBG mRNA levels in the endometria of low serum midluteal progesterone level were significantly (p < 0.05) reduced and raised, respectively, compared with normal levels. These findings suggest that the synthesis of endometrial steroid-binding proteins in the out-of-phase endometrium is conserved, as that in the in-phase endometrium, whereas the decreased progesterone level might up-regulate CBG expression with down-regulation of SHBG expression.
Authors:
R Misao; Y Nakanishi; J Fujimoto; T Tamaya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  9     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-02-08     Completed Date:  1996-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Base Sequence
Endometrium / metabolism
Estradiol / blood
Female
Gene Expression
Humans
Infertility, Female / metabolism*
Luteal Phase*
Molecular Sequence Data
Polymerase Chain Reaction
Progesterone / blood
RNA, Messenger / metabolism*
Sex Hormone-Binding Globulin / genetics*
Transcortin / genetics*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 0/Sex Hormone-Binding Globulin; 50-28-2/Estradiol; 57-83-0/Progesterone; 9010-38-2/Transcortin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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