Document Detail


Sex hormone-binding globulin as a marker for the thrombotic risk of hormonal contraceptives: a rebuttal.
MedLine Citation:
PMID:  23140257     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In a recent manuscript Raps et al (1) used the correlation between sex hormone-binding globulin (SHBG) and the normalised APC sensitivity ratio (nAPCsr) as an argument for using SHBG as a useful marker to estimate thrombotic risk of a hormonal contraceptive preparation. They present a log-normal association of SHBG with nAPCsr with an R(2) linear value of 0.476. We had the opportunity to verify this association in the large seven pill study in which nAPCsr was known (2). © 2012 International Society on Thrombosis and Haemostasis.
Authors:
C Kluft; S O Skouby; J Jespersen; J Burggraaf
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Publication Detail:
Type:  LETTER     Date:  2012-11-12
Journal Detail:
Title:  Journal of thrombosis and haemostasis : JTH     Volume:  -     ISSN:  1538-7836     ISO Abbreviation:  J. Thromb. Haemost.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101170508     Medline TA:  J Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Society on Thrombosis and Haemostasis.
Affiliation:
Good Biomarker Sciences, Leiden, The Netherlands and Department for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark and Centre for Human Drug Research, Leiden, The Netherlands Dep. Ob/Gyn. Herlev Hospital, University of Copenhagen, Denmark and Department for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark Department for Thrombosis Research, University of Southern Denmark, Esbjerg, Denmark Centre for Human Drug Research, Leiden, The Netherlands.
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