Document Detail

Sex and gestational age effects on auditory brainstem responses in preterm and term infants.
MedLine Citation:
PMID:  22849808     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Some studies find delayed development of the auditory brainstem in preterm infants, but others do not.
AIM: To compare auditory brainstem responses (ABRs) in healthy preterm and term infants depending on sex and gestational age (GA).
METHODS: Participants were 111 preterm (27-36weeks GA) and 92 term (37-41weeks GA) infants. ABR tests were conducted at 6weeks (corrected age if preterm).
RESULTS: There were no overall differences between term and preterm groups in ABRs. However, males showed longer latencies for waves III, V, and I-III, III-V, and I-V intervals and smaller amplitudes for wave III and V than females in both preterm and term groups (all p values≤.01). A 3-way interaction between group, sex, and GA (p<.05) showed that preterm males with later GA had longer wave I-V interval, whereas term females with later GA showed shorter wave I-V interval. Growth velocity predicted wave I-V interval in preterm infants, controlling for other factors (male: p=.07, female: p<.05).
CONCLUSION: ABRs in preterm and term infants were similar at 6weeks (corrected age if preterm), but males had less advanced ABRs than females. More rapid growth predicted less mature ABR in later GA preterm infants in this setting where they were unlikely to receive extra iron. The roles of GA, growth, and iron balance in ABR development warrant further study.
Mingyan Li; Li Zhu; Xiaoqin Mai; Jie Shao; Betsy Lozoff; Zhengyan Zhao
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-31
Journal Detail:
Title:  Early human development     Volume:  89     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-14     Completed Date:  2013-06-05     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  43-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Auditory Pathways*
Brain Stem / physiology*
Gestational Age*
Infant, Newborn
Sex Factors*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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