Document Detail


Sex, genetics, and the control of thyroxine and thyrotropin in mice.
MedLine Citation:
PMID:  24564389     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Previously, we studied the genetic basis for variability in total thyroxine (TT4) as part of investigating induced Graves' hyperthyroidism in panels of genetically diverse recombinant inbred (RI) mice. Because Graves' disease occurs predominantly in women, we used female mice. A limitation of this approach is that thyrotropin (TSH) is undetectable by some assays in most female mice.
METHOD: Variation in levels of serum TSH, TT4, and free thyroxine (FT4) was measured in males from three related RI families (CXB, BXH, and AXBXA) followed by quantitative genetic analysis and mapping of these traits.
RESULTS: In general, TSH levels were higher in males than females. FT4 levels were also higher in males than in females, but TT4 sex differences were absent or inconsistent. Chromosomal linkage was only observed for TSH in BXH males and for FT4 in AXBXA males. Different chromosomes were linked to TT4 in males of the three RI sets. The most striking finding came from genetic linkages in males versus our previous data for females. TT4 was linked to the same chromosomal loci in CXB males and females. In contrast, TT4, FT4, and TSH were linked to different "sex-specific chromosomes" in AXBXA and BXH families.
CONCLUSIONS: In three RI mouse families, TSH and FT4 were significantly higher in males than females. Linkage analysis revealed chromosomal overlap for TT4 in males and females for one RI set but striking sex differences for TT4, FT4, and TSH linkage in two RI sets. Our findings provide a cautionary note: genetic linkage analysis of thyroid hormones traits in mice should be studied separately in males and females.
Authors:
Sandra M McLachlan; Sepehr Hamidi; Holly Aliesky; Robert W Williams; Basil Rapoport
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2014-05-22
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  24     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-04     Completed Date:  -     Revised Date:  2014-12-02    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1080-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
DK54684/DK/NIDDK NIH HHS; P20-DA-21131/DA/NIDA NIH HHS; R01 DK082390/DK/NIDDK NIH HHS; U01 AA016662/AA/NIAAA NIH HHS; U01AA13499/AA/NIAAA NIH HHS; U01CA105417/CA/NCI NIH HHS; U24AA13513/AA/NIAAA NIH HHS; U24RR021760/RR/NCRR NIH HHS

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