Document Detail

Sex, fat and the tilt of the earth: effects of sex and season on the feeding response to centrally administered leptin in sheep.
MedLine Citation:
PMID:  11356725     Owner:  NLM     Status:  MEDLINE    
Whilst there have been many studies in various species examining the effects of leptin on food intake, there is a paucity of data comparing responsiveness in the two sexes. We have, therefore, addressed this issue in sheep. Because this species shows seasonal variation in voluntary food intake (VFI), we also considered the possibility that there might be seasonal variation in the responsivity to leptin. Centrally administered leptin was relatively ineffective as a satiety factor in either sex during AUTUMN: In Spring, leptin had a profound inhibitory effect on VFI in the females, but only a slight effect in males. These data indicate that responsiveness to leptin depends on sex and also on season in animals that are substantially affected by photoperiod.
I J Clarke; A J Tilbrook; A I Turner; B W Doughton; J W Goding
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Endocrinology     Volume:  142     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-17     Completed Date:  2001-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2725-8     Citation Subset:  AIM; IM    
Prince Henry's Institute of Medical Research, Clayton, Victoria 3168, Australia.
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MeSH Terms
Body Weight
Eating / drug effects*
Leptin / administration & dosage,  pharmacology*
Satiation / drug effects
Sex Characteristics*
Reg. No./Substance:

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