| Sex differentiation disorders (SDD) prenatal sonographic diagnosis, genetic and hormonal work-up. | |
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MedLine Citation:
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PMID: 19696712 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gender is determined by the genetic, gonadal and hormonal/ phenotypic sex. Genetic sex is determined at conception. The establishment of the gonadal sex (ovary/testis) and the phenotypic sex (external and internal genitalia) is a complicated multistep process which is determined during fetal life mainly during the first trimester. Recently more genes have been found to be involved in this process. Prenatal diagnosis of fetal gender can be made using ultrasound technology, genetic and hormonal examinations. Nowadays using a vaginal and abdominal transducer for US examination recognition of external and internal genitalia of both genders is possible. The determination of gender during fetal life is important not only as a matter of curiosity; in some cases of ambiguity (for example congenital adrenal hyperplasia) prenatal treatment can change the natural history of the disease. Prenatal diagnosis can also subtype the ambiguity, and its severity can be established. In this review we describe our experience in prenatal diagnosis and establishment of the fetal gender, the subtypes of ambiguity and our suggestion for the process of diagnostic work-up. |
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Authors:
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Eldad Katorza; Orit Pinhas-Hamiel; Ram Mazkereth; Yinon Gilboa; Reuven Achiron |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pediatric endocrinology reviews : PER Volume: 7 ISSN: 1565-4753 ISO Abbreviation: Pediatr Endocrinol Rev Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-21 Completed Date: 2009-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101202124 Medline TA: Pediatr Endocrinol Rev Country: Israel |
Other Details:
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Languages: eng Pagination: 12-21 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, Israel. eldad210@bezeqint.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Genetic Screening Genitalia / embryology, ultrasonography Gestational Age Gonadal Steroid Hormones / metabolism Humans Male Practice Guidelines as Topic Pregnancy Sex Differentiation Disorders / diagnosis*, embryology, metabolism Ultrasonography, Prenatal |
| Chemical | |
Reg. No./Substance:
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0/Gonadal Steroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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