| Sex differences precipitating anorexia nervosa in females: the estrogen paradox and a novel framework for targeting sex-specific neurocircuits and behavior. | |
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MedLine Citation:
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PMID: 21769727 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In anorexia nervosa (AN), reward contamination likely plays a significant role in maintenance of the illness. Reward contamination is a context in which patients' behaviors of self-starvation and excessive exercise, while initially rewarding, become aversive, even punishing; but patients may not recognize the punishing and conflicted/contaminated behaviors. An emerging neurocircuit encompassing the anterior cingulate cortex (ACC) has been functionally linked to symptoms including reward contamination and body dysmorphic processing. Owing to the significantly greater prevalence of AN in females, evidence from clinical literature and preclinical models is spearheaded to provide a novel rationale for estrogen triggering sensitivity to the experience of stress and reward, precipitating AN disproportionately in females at the time of puberty. Paradoxically, however, estrogen may facilitate response to pharmacological interventions and (desensitization of the identified neurocircuits) via its contribution to serotonin modulation, hypothalamo-pituitary adrenal (HPA)-axis attenuation, and effects on dopamine. |
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Authors:
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Charlotte Keating |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current topics in behavioral neurosciences Volume: 8 ISSN: 1866-3370 ISO Abbreviation: Curr Top Behav Neurosci Publication Date: 2011 |
Date Detail:
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Created Date: 2011-07-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101535383 Medline TA: Curr Top Behav Neurosci Country: Germany |
Other Details:
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Languages: eng Pagination: 189-207 Citation Subset: IM |
Affiliation:
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Monash Alfred Psychiatry Research Centre (MAPrc), The Alfred Hospital, 1st floor, Old Baker Building, Commercial Road, Prahran, VIC, 3181, Australia, charlottekeating1@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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