Document Detail


Sex differences in upper respiratory symptoms prevalence and oral-respiratory mucosal immunity in endurance athletes.
MedLine Citation:
PMID:  24974718     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The purpose of this study was to examine sex differences in oral-respiratory mucosal immunity and the incidence, severity and duration of upper respiratory symptoms (URS) episodes in endurance athletes during a 16-week winter training period. Blood was collected from 210 subjects (147 men and 63 women) at the start and end of the study for determination of differential leukocyte counts. Timed collections of unstimulated saliva were obtained at the start and at 4-week intervals during the study period. Saliva samples were analysed for salivary antimicrobial peptides and proteins (AMPs). Weekly training and daily illness logs were kept using validated questionnaires. Training loads averaged 11 h/week of moderate-vigorous physical activity and were not different for males and females. The salivary concentration of lysozyme and lactoferrin (both P < 0.04) but not salivary immunoglobulin A (SIgA) or amylase were higher in males than females. Saliva flow rates were significantly higher in males than females (P < 0.03) and consequently so were the salivary secretion rates of lysozyme, lactoferrin and amylase (all P < 0.01) but not SIgA (P = 0.097). Total blood leukocyte, monocyte and lymphocyte counts were not different between the sexes but females had higher numbers of circulating neutrophils (P = 0.040). The average number of URS episodes was 0.6 +/- 0.8 (mean +/- SD) in males and 0.8 +/- 1.0 in females (P = 0.103) and the number of URS days was higher in females (4.7 vs 6.8 days, P < 0.02). The duration of URS episodes was longer in females (11.6 vs 15.5 days, P < 0.03). The findings of this study concur with recent reports of illness incidence at major competitive games indicating that female athletes may be more susceptible than their male counterparts to URS and that lower oral-respiratory mucosal immunity may, in part, account for this.
Authors:
Cheng-Shiun He; Nicolette C Bishop; Michal K Handzlik; Ayu S Muhamad; Michael Gleeson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Exercise immunology review     Volume:  20     ISSN:  1077-5552     ISO Abbreviation:  Exerc Immunol Rev     Publication Date:  2014  
Date Detail:
Created Date:  2014-06-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505535     Medline TA:  Exerc Immunol Rev     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  8-22     Citation Subset:  IM    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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