| Sex differences in salt sensitivity to nitric oxide dependent vasodilation in healthy young adults. | |
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MedLine Citation:
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PMID: 22194324 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Dietary sodium and blood pressure regulation differs between normotensive men and women, an effect which may involve endothelial production of nitric oxide (NO). Therefore, we tested the hypothesis that differences in the NO component of endothelium-dependent vasodilation between low and high dietary sodium intake depend on sex. For 5 days prior to study, healthy adults consumed a controlled low sodium diet (10 mmol/day, n=30, mean age±SEM: 30±1 yr, 16 men) or high sodium diet (400 mmol/day, n=36, age 23±1 yr, 13 men). Forearm blood flow (FBF, plethysmography) responses to brachial artery administration of acetylcholine (ACh, 4 mcg/100 ml tissue/min) were measured before and after endothelial NO synthase inhibition with N(G)-monomethyl-L-arginine (L-NMMA, 50 mg bolus + 1 mg/min infusion). The NO component of endothelium-dependent dilation was calculated as the response to ACh before and after L-NMMA accounting for changes in baseline FBF: [(FBF ACh - FBF baseline) - (FBF ACh(L-NMMA) - FBF baseline(L-NMMA))]. This value was 5.7±1.3 and 2.5±0.8 ml/100 ml forearm tissue/min for the low and high sodium diets, respectively (main effect of sodium, P=0.019). The sodium effect was larger for the men, with values of 7.9±2.0 and 2.2±1.4 for men versus 3.1±1.3 and 2.7±1.0 ml/100 ml forearm tissue/min for the women (P=0.034, sex-by-sodium interaction). We conclude that the NO component of endothelium-dependent vasodilation is altered by dietary sodium intake based on sex, suggesting that endothelial NO production is sensitive to dietary sodium in healthy young men but not women. |
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Authors:
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John H Eisenach; Leah R Gullixson; Susan L Kost; Michael J Joyner; Stephen T Turner; Wayne T Nicholson |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-22 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Mayo Clinic. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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