| Sex differences in response to treatments for chronic coronary artery disease. | |
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MedLine Citation:
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PMID: 19898277 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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More women than men die of coronary artery disease (CAD) each year. In women, cardiovascular disease can present atypically and may be caused by small vessel disease rather than by major epicardial coronary luminal narrowing. Women with CAD tend to have more diffuse disease, endothelial dysfunction, and microvascular disease than men. In those studies that have looked at sex differences in treatment response, sex-specific physiologic, pharmacokinetic, and pharmacodynamic differences appear to be the cause. Women have smaller hearts, higher heart rates, shorter cardiac cycle lengths, and longer QT intervals than men. CAD medical treatments such as antiplatelet agents, anticoagulants, beta-blockers, and antithrombin agents may have different effects in women and men. Only 30% of percutaneous coronary interventions are performed in women. Women are less likely than men to undergo diagnostic angiography and are more likely to experience delays in treatment. |
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Authors:
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Molly Szerlip; Cindy L Grines |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews in cardiovascular medicine Volume: 10 Suppl 2 ISSN: 1530-6550 ISO Abbreviation: Rev Cardiovasc Med Publication Date: 2009 |
Date Detail:
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Created Date: 2009-11-09 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960007 Medline TA: Rev Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: S14-23 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Medicine, William Beaumont Hospital, Royal Oak, MI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon, Coronary* Cardiovascular Agents / therapeutic use* Coronary Artery Bypass* Coronary Artery Disease / diagnosis, therapy* Evidence-Based Medicine Female Health Status Disparities Healthcare Disparities Humans Male Sex Factors Treatment Outcome Women's Health |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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