Document Detail


Sex differences in the resistive and elastic work of breathing during exercise in endurance-trained athletes.
MedLine Citation:
PMID:  19420295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is not known whether the high total work of breathing (WOB) in exercising women is higher due to differences in the resistive or elastic WOB. Accordingly, the purpose of this study was to determine which factors contribute to the higher total WOB during exercise in women. We performed a comprehensive analysis of previous data from 16 endurance-trained subjects (8 men and 8 women) that underwent a progressive cycle exercise test to exhaustion. Esophageal pressure, lung volumes, and ventilatory parameters were continuously monitored throughout exercise. Modified Campbell diagrams were used to partition the esophageal-pressure volume data into inspiratory and expiratory resistive and elastic components at 50, 75, 100 l/min and maximal ventilations and also at three standardized submaximal work rates (3.0, 3.5, and 4.0 W/kg). The total WOB was also compared between sexes at relative submaximal ventilations (25, 50, and 75% of maximal ventilation). The inspiratory resistive WOB at 50, 75, and 100 l/min was 67, 89, and 109% higher in women, respectively (P < 0.05). The expiratory resistive WOB was 131% higher in women at 75 l/min (P < 0.05) with no differences at 50 or 100 l/min. There were no significant sex differences in the inspiratory or expiratory elastic WOB across any absolute minute ventilation. However, the total WOB was 120, 60, 50, and 45% higher in men at 25, 50, 75, and 100% of maximal exercise ventilation, respectively (P < 0.05). This was due in large part to their much higher tidal volumes and thus higher inspiratory elastic WOB. When standardized for a given work rate to body mass ratio, the total WOB was significantly higher in women at 3.5 W/kg (239 +/- 31 vs. 173 +/- 12 J/min, P < 0.05) and 4 W/kg (387 +/- 53 vs. 243 +/- 36 J/min, P < 0.05), and this was due exclusively to a significantly higher inspiratory and expiratory resistive WOB rather than differences in the elastic WOB. The higher total WOB in women at absolute ventilations and for a given work rate to body mass ratio is due to a substantially higher resistive WOB, and this is likely due to smaller female airways relative to males and a breathing pattern that favors a higher breathing frequency.
Authors:
Jordan A Guenette; Jordan S Querido; Neil D Eves; Romeo Chua; A William Sheel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-06
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  297     ISSN:  1522-1490     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-03     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R166-75     Citation Subset:  IM    
Affiliation:
School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Airway Resistance*
Bicycling
Body Weight
Elasticity
Esophagus / physiology
Female
Humans
Lung / anatomy & histology,  physiology*
Lung Volume Measurements
Male
Muscle Contraction*
Physical Endurance*
Pressure
Pulmonary Ventilation
Respiration*
Respiratory Mechanics
Respiratory Muscles / physiology*
Sex Factors
Tidal Volume
Work of Breathing*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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