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Sex differences in the prevalence of congenital anomalies: A population-based study.
MedLine Citation:
PMID:  21987467     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Limited data is available concerning the sex distribution of various congenital anomaly subtypes. This study investigated sex differences in the prevalence of congenital anomalies, overall and by subtype, using high quality population-based data from the North of England.
METHODS: Information on congenital anomalies occurring among singleton pregnancies during 1985-2003 were extracted from the Northern Congenital Abnormality Survey (NorCAS). Anomalies were categorized by groups, subtypes, and syndromes according to the European Surveillance of Congenital Anomalies guidelines. Relative risks (RRs) comparing the prevalences in males to that in females were calculated for a range of congenital anomaly subtypes.
RESULTS: A total of 12,795 eligible cases of congenital anomaly were identified during the study period, including 7019 (54.9%) males and 5776 (45.1%) females. Overall, male fetuses were significantly more prevalent in pregnancies affected by a congenital anomaly than female fetuses (RR, male vs. female = 1.15; 95% confidence interval [CI], 1.11-1.19), but there was significant heterogeneity between subtypes (p < 0.001). Forty-four of 110 (40%) unique subtypes were at least 40% more prevalent in males than females, with affected subtypes occurring across all major anomaly groups. Thirteen of 110 (12%) unique subtypes were at least 40% more prevalent in females than males, but the female-biased RR of a neural tube defect was less pronounced than previously reported (RR = 0.84; 95% CI, 0.73-0.95).
CONCLUSION: This study adds to the growing evidence of sex-specific differences in the prevalence of a wide range of congenital anomaly subtypes. Birth Defects Research (Part A), 2011. © 2011 Wiley-Liss, Inc.
Authors:
Peter W G Tennant; S Dilhani Samarasekera; Tanja Pless-Mulloli; Judith Rankin
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Publication Detail:
Type:  Journal Article     Date:  2011-08-24
Journal Detail:
Title:  Birth defects research. Part A, Clinical and molecular teratology     Volume:  91     ISSN:  1542-0760     ISO Abbreviation:  Birth Defects Res. Part A Clin. Mol. Teratol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101155107     Medline TA:  Birth Defects Res A Clin Mol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  894-901     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Institute of Health & Society, Baddiley-Clark Building, Newcastle University, Newcastle upon Tyne, NE2 4AX, England, United Kingdom.
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