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Sex differences in physiological cardiac hypertrophy are associated with exercise-mediated changes in energy substrate availability.
MedLine Citation:
PMID:  21478409     Owner:  NLM     Status:  Publisher    
Exercise-induced cardiac hypertrophy has been recently identified to be regulated in a sex-specific manner. In parallel, women exhibit enhanced exercise-mediated lipolysis when compared to men, which might be linked to cardiac responses. The aim of the present study was to assess if previously reported sex-dependent differences in the cardiac hypertrophic response during exercise are associated with differences in cardiac energy substrate availability/ utilization. Female and male C57BL/6J mice were challenged with active treadmill running for 1.5h/day (0.25m/s) over 4 weeks. Mice underwent cardiac and metabolic phenotyping including echocardiography, small-animal PET, peri-exercise indirect calorimetry, analysis of adipose tissue (AT) lipolysis and cardiac gene expression. Female mice exhibited increased cardiac hypertrophic responses to exercise when compared to male mice, measured by echocardiography (percent increase in left ventricular mass (LVM): female: 22.2±0.8%, male: 9.0±0.2%; p<0.05). This was associated with increased plasma free fatty acid (FFA) levels and augmented AT lipolysis in female mice after training, whereas FFA levels from male mice decreased. The respiratory quotient during exercise was significantly lower in female mice indicative for preferential utilization of fatty acids. In parallel, myocardial glucose uptake was reduced in female mice after exercise, analyzed by PET (injection dose (ID)/LVM [%ID/g]: 36.8±3.5 (female sedentary vs. 28.3±4.3 female training, p<0.05), whereas cardiac glucose uptake was unaltered after exercise in male counterparts. Cardiac genes involved in FA uptake/oxidation in females were increased compared to male mice. Collectively, our data demonstrate that sex differences in exercise-induced cardiac hypertrophy are associated with changes in cardiac substrate availability and utilization.
Anna Foryst-Ludwig; Michael C Kreissl; Christiane Sprang; Beata Thalke; Christian Böhm; Verena Benz; Dennis Gürgen; Duska Dragun; Carola Schubert; Knut Mai; Philipp Stawowy; Joachim Spranger; Vera Regitz-Zagrosek; Thomas Unger; Ulrich Kintscher
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-8
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Center for Cardiovascular Research (CCR Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Germany.
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