| Sex differences in (-)-pentazocine antinociception: comparison to morphine and spiradoline in four rat strains using a thermal nociceptive assay. | |
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MedLine Citation:
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PMID: 12576884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examined the influence of sex on the antinociceptive effects of (-)-pentazocine, morphine and spiradoline in four rat strains, using a warm-water (50, 52 and 55 degrees C) tail-withdrawal procedure. In F344, Lewis, Sprague-Dawley (SD) and Wistar rats, baseline latencies decreased with increases in water temperature, and at each water temperature latencies were longer in males than in their female counterparts. Morphine and spiradoline produced maximal or near maximal antinociceptive effects in males and females of each strain. Whereas morphine was generally more potent in males, sex differences were not consistently observed with spiradoline. In contrast, there were marked sex differences with (-)-pentazocine, and in each strain (-)-pentazocine was more potent and produced a greater maximal effect in males. The magnitude of the sex differences varied markedly across strains, with (-)-pentazocine being 2.5-fold more potent in males of the F344 strain, but 11-fold more potent in males of the Wistar strain. When collapsed across nociceptive stimulus intensities, sex differences were largest in the Wistar and Lewis strains and smallest in the SD and F344 strains. The present findings indicate that there are marked sex differences in (-)-pentazocine antinociception, and that the magnitude of this effect is genotype dependent. |
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Authors:
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J M Terner; A C Barrett; C D Cook; M J Picker |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Behavioural pharmacology Volume: 14 ISSN: 0955-8810 ISO Abbreviation: Behav Pharmacol Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-10 Completed Date: 2003-07-02 Revised Date: 2009-07-07 |
Medline Journal Info:
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Nlm Unique ID: 9013016 Medline TA: Behav Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 77-85 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3270, USA. terner@email.unc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacology* Analgesics, Opioid / pharmacology Animals Dose-Response Relationship, Drug Female Male Morphine / pharmacology* Pain Measurement Pentazocine / pharmacology* Pyrrolidines / pharmacology* Rats Rats, Inbred F344 Rats, Inbred Lew Rats, Sprague-Dawley Rats, Wistar Sex Factors Species Specificity |
| Grant Support | |
ID/Acronym/Agency:
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DA05888/DA/NIDA NIH HHS; DA10277/DA/NIDA NIH HHS; DA15273/DA/NIDA NIH HHS; MH07431/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Analgesics, Opioid; 0/Pyrrolidines; 359-83-1/Pentazocine; 57-27-2/Morphine; 87151-85-7/spiradoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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