| Sex differences in parietal lobe structure and development. | |
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MedLine Citation:
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PMID: 22333522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Structural magnetic resonance imaging studies provide evidence for sex differences in the human brain. Differences in surface area and the proportion of gray to white matter volume are observed, in particular in the parietal lobe. To our knowledge, no studies have examined sex differences in parietal lobe structure in younger populations or in the context of development. The present study evaluated sex differences in the structure of the parietal lobe in children aged 7 to 17 years. In addition, by adding a cohort of previously studied adults aged 18 to 50 years, sex differences in parietal lobe structure were examined across the age span of 7 to 50 years. Compared with the adult sample, the younger sample showed that the ratio of parietal lobe cortex to white matter was greater in female brains, but no sex differences in surface area. When examining the effects of age, surface area exhibited a significant sex-age interaction. In male brains, there was essentially no decrease in surfaces area over time, whereas in female brains, there was a significant decrease in surface area over time. These findings support the notion of structural sex differences in the parietal lobe, not only in the context of cross-sectional assessment but also in terms of differences in developmental trajectories. |
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Authors:
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Joel Salinas; Elizabeth D Mills; Amy L Conrad; Timothy Koscik; Nancy C Andreasen; Peg Nopoulos |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gender medicine Volume: 9 ISSN: 1878-7398 ISO Abbreviation: Gend Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-15 Completed Date: 2012-10-24 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 101225178 Medline TA: Gend Med Country: United States |
Other Details:
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Languages: eng Pagination: 44-55 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier HS Journals, Inc. All rights reserved. |
Affiliation:
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University of Iowa Doris Duke Clinical Research Fellowship Program, Iowa City, Iowa 52242, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Analysis of Variance Brain / anatomy & histology Child Cross-Sectional Studies Female Humans Magnetic Resonance Imaging Male Middle Aged Parietal Lobe / anatomy & histology, growth & development* Sex Characteristics Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 DE01 14399 01 A12/DE/NIDCR NIH HHS; MH31593/MH/NIMH NIH HHS; MH40856/MH/NIMH NIH HHS; MH43271/MH/NIMH NIH HHS; P30 MH043271-13/MH/NIMH NIH HHS; R01 DE014399-01A1/DE/NIDCR NIH HHS; R01 MH031593-17A1/MH/NIMH NIH HHS; R01 MH040856-12A1/MH/NIMH NIH HHS; RR00059/RR/NCRR NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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