| Sex differences in naloxone- and Tyr-MIF-1-induced hypoalgesia. | |
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MedLine Citation:
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PMID: 7904339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reproductive adult male and female deer mice that received daily (7 days) injections of either the prototypic exogenous opiate antagonist, naloxone (1.0 mg/kg), or the endogenous putative antiopioid tetrapeptide, Tyr-MIF-1 (Tyr-Pro-Leu-Gly amide; 1.0 and 10 mg/kg), followed by determinations of thermal nociceptive sensitivity (hot-plate response) developed hypoalgesia. There were significant sex differences in this opioid blockade-induced or associated analgesia, with male mice displaying significantly greater hypoalgesia than females. Mice that received daily injections of either naloxone or Tyr-MIF-1 for 7 days without any accompanying determinations of nociceptive sensitivity (days 2-6 of treatment) failed to show any hypoalgesia on day 7 when they received the antagonist followed by a measurement of nociception. These results indicate that there are sex differences in both naloxone- and Tyr-MIF-1-induced hypoalgesia, and suggest that this pattern may be associated with sexually dimorphic opioid modulation of aversive conditioning. |
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Authors:
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M Kavaliers; D G Innes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peptides Volume: 14 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1993 Sep-Oct |
Date Detail:
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Created Date: 1994-02-14 Completed Date: 1994-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1001-4 Citation Subset: IM |
Affiliation:
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Division of Oral Biology, Faculty of Dentistry, University of Western Ontario, London, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female MSH Release-Inhibiting Hormone / analogs & derivatives*, pharmacology Male Naloxone / pharmacology* Pain / physiopathology* Peromyscus Sex Characteristics* |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 77133-61-0/tyrosyl-prolyl-leucyl-glycinamide; 9083-38-9/MSH Release-Inhibiting Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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