Document Detail

Sex differences in muscarinic receptor binding after chronic ethanol administration in the rat.
MedLine Citation:
PMID:  3101109     Owner:  NLM     Status:  MEDLINE    
Male and female rats were administered ethanol (5% v/v) in a liquid diet for 18 weeks. Pair-fed control animals were fed the same diet except that dextrose was substituted isocalorically for ethanol. Normal controls received a commercial laboratory chow for the same duration. Results showed that, in females, chronic ingestion of an ethanol liquid diet significantly increased the number of muscarinic receptor binding sites compared to both control groups. In contrast, for males, there was no significant difference in the mean number of binding sites among the treatment groups. Furthermore, the mean maximum number of binding sites for males and females varied across brain areas. Males had a significantly greater number of receptor binding sites than females in the striatum, while females had a greater number in the cortex. It was suggested that the geuder differences observed in the present study could be mediated by hormonal effects on central muscarinic functioning.
E D Witt; C R Mantione; I Hanin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  90     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-20     Completed Date:  1987-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  537-42     Citation Subset:  IM    
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MeSH Terms
Alcoholism / metabolism*
Body Weight / drug effects
Brain / metabolism*
Cerebral Cortex / metabolism
Corpus Striatum / metabolism
Quinuclidinyl Benzilate / metabolism
Receptors, Muscarinic / drug effects*,  metabolism
Sex Characteristics
Grant Support
Reg. No./Substance:
0/Receptors, Muscarinic; 6581-06-2/Quinuclidinyl Benzilate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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