Document Detail


Sex differences in muscarinic receptor binding after chronic ethanol administration in the rat.
MedLine Citation:
PMID:  3101109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Male and female rats were administered ethanol (5% v/v) in a liquid diet for 18 weeks. Pair-fed control animals were fed the same diet except that dextrose was substituted isocalorically for ethanol. Normal controls received a commercial laboratory chow for the same duration. Results showed that, in females, chronic ingestion of an ethanol liquid diet significantly increased the number of muscarinic receptor binding sites compared to both control groups. In contrast, for males, there was no significant difference in the mean number of binding sites among the treatment groups. Furthermore, the mean maximum number of binding sites for males and females varied across brain areas. Males had a significantly greater number of receptor binding sites than females in the striatum, while females had a greater number in the cortex. It was suggested that the geuder differences observed in the present study could be mediated by hormonal effects on central muscarinic functioning.
Authors:
E D Witt; C R Mantione; I Hanin
Related Documents :
11293469 - Effect of alcohol on postprandial lipemia with and without preprandial exercise.
15054259 - Conversion of distiller's grain into fuel alcohol and a higher-value animal feed by dil...
11989779 - Morphology of the seminal vesicle of calomys callosus submitted to experimental chronic...
2622989 - Ethanol stimulation after chronic exposure in c57 mice.
8659689 - Effect of vitamin e deficiency on inhibition of liver regeneration by long-term adminis...
8412749 - The body composition and lipid metabolic effects of long-term ethanol feeding during a ...
14753369 - Evaluation of methods to reduce bacteria concentrations in spray-dried animal plasma an...
864759 - Suppression of dibutylnitrosamine-induced bladder carcinomas in hamsters by dietary ind...
17708629 - Improvement of sperm production in subfertile boars by cordyceps militaris supplement.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychopharmacology     Volume:  90     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1986  
Date Detail:
Created Date:  1987-03-20     Completed Date:  1987-03-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  537-42     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alcoholism / metabolism*
Animals
Body Weight / drug effects
Brain / metabolism*
Cerebral Cortex / metabolism
Corpus Striatum / metabolism
Female
Male
Quinuclidinyl Benzilate / metabolism
Rats
Receptors, Muscarinic / drug effects*,  metabolism
Sex Characteristics
Grant Support
ID/Acronym/Agency:
MH26320/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Muscarinic; 6581-06-2/Quinuclidinyl Benzilate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cigarette withdrawal symptoms in adolescent smokers.
Next Document:  The effect of training dose on discrimination of compound drug-exteroceptive stimuli.