| Sex differences in the modulation of vasomotor sympathetic outflow during static handgrip exercise in healthy young humans. | |
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MedLine Citation:
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PMID: 21508291 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Sex differences in sympathetic neural control during static exercise in humans are few and the findings are inconsistent. We hypothesized women would have an attenuated vasomotor sympathetic response to static exercise, which would be further reduced during the high sex hormone (mid-luteal, ML) vs. the low hormone phase (early follicular, EF). We measured heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) in 11 women and 10 men during a cold pressor test (CPT) and static handgrip to fatigue with 2 min of post-exercise circulatory arrest (PECA). HR increased during handgrip, reached its peak at fatigue, and was comparable between sexes. BP increased during handgrip and PECA where men had larger increases from baseline. Mean (±SD) MSNA burst frequency (BF) during handgrip and PECA was lower in women (EF, p<0.05), as was ΔMSNA-BF smaller (main effect, both p<0.01). Δtotal activity was higher in men at fatigue (EF: 632±418 vs. ML: 598±342 vs. men: 1025±416 a.u./min, p<0.001 for EF and ML vs. men) and during PECA (EF: 354±321 vs. ML: 341±199 vs. men: 599±327 a.u./min, p<0.05 for EF and ML vs. men). During CPT, HR and MSNA responses were similar between sexes and hormone phases, confirming that central integration and the sympathetic efferent pathway was comparable between the sexes and across hormone phases. Women demonstrated a blunted metaboreflex, unaffected by sex hormones, which may be due to differences in muscle mass or fiber type and, therefore, metabolic stimulation of group IV afferents. |
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Authors:
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Sara S Jarvis; Tiffany B Vangundy; M Melyn Galbreath; Shigeki Shibata; Kazunobu Okazaki; Miriam F Reelick; Benjamin D Levine; Qi Fu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-20 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Texas Southwestern Medical Center. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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