| Sex differences in microglial colonization of the developing rat brain. | |
| | |
MedLine Citation:
|
PMID: 22182318 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Microglia are the resident immune cells within the brain and their production of immune molecules such as cytokines and chemokines is critical for the processes of normal brain development including neurogenesis, axonal migration, synapse formation, and programmed cell death. Notably, sex differences exist in many of these processes throughout brain development; however, it is unknown whether a sex difference concurrently exists in the colonization, number, or morphology of microglia within the developing brain. We demonstrate for the first time that the number and morphology of microglia throughout development is dependent upon the sex and age of the individual, as well as the brain region of interest. Males have overall more microglia early in postnatal development (postnatal day (P) 4), whereas females have more microglia with an activated/amoeboid morphology later in development, as juveniles and adults (P30-60). Finally, gene expression of a large number of cytokines, chemokines and their receptors shifts dramatically over development, and is highly dependent upon sex. Taken together, these data warrant further research into the role that sex-dependent mechanisms may play in microglial colonization, number, and function, and their potential contribution to neural development, function, or potential dysfunction. © 2011 The Authors Journal of Neurochemistry© 2011 International Society for Neurochemistry. |
| | |
Authors:
|
Jaclyn M Schwarz; Paige W Sholar; Staci D Bilbo |
Related Documents
:
|
17885208 - Nfatc1 induces osteoclast fusion via up-regulation of atp6v0d2 and the dendritic cell-s... 17086898 - Interferon-beta modulates bone-associated cytokines and osteoclast precursor activity i... 19860668 - Dendritic cells: a new player in osteoimmunology. 9824538 - Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward th... 15184078 - Triptolide (pg-490) induces apoptosis of dendritic cells through sequential p38 map kin... 21884168 - Dsrna sensors and plasmacytoid dendritic cells in host defense and autoimmunity. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-19 |
Journal Detail:
|
Title: Journal of neurochemistry Volume: - ISSN: 1471-4159 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Authors Journal of Neurochemistry © 2011 International Society for Neurochemistry. |
Affiliation:
|
Department of Psychology and Neuroscience, Duke University, 572 Research Drive, Box 91050, Durham, NC 27705. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Adsorption Behavior of Microbes on a QCM Chip Modified with an Artificial Siderophore-Fe(3+) Complex...
Next Document: Narcolepsy and sleep-disordered breathing.