Document Detail

Sex differences in medial and lateral orbitofrontal cortex hypoperfusion in cocaine-dependent men and women.
MedLine Citation:
PMID:  17081954     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The different clinical trajectories of cocaine-dependent men and women may be a consequence of distinct neurobiological substrates. Hypoperfusion of the orbitofrontal cortex (OFC) has previously been reported in individuals addicted to cocaine and has been posited as a biological mediator of relapse due to impulsivity or impaired decision making.
OBJECTIVE: This study assessed regional cerebral blood flow (rCBF) between abstinent cocaine-dependent men and women and sex-matched healthy controls.
METHODS: Cocaine-dependent subjects were abstinent from cocaine for 11 to 28 days and had no other major mental health or substance use disorders. rCBF was assessed with single photon emission computed tomography after administration of a placebo saline infusion. A resting scan was also obtained in a subset of cocaine-dependent and control men.
RESULTS: In the 35 cocaine-dependent and 37 healthy control subjects examined, a sex-by-group effect was observed for the left lateral (P=0.001), right lateral (P=0.002), and medial (P<0.02) OFC. Cocaine-dependent men demonstrated significantly lower right and left lateral, but not medial, OFC rCBF compared with sex-matched healthy controls after placebo infusion (P<or=0.001). Similar bilateral OFC decreases were observed in male cocaine-dependent subjects at rest. In contrast, cocaine-dependent women showed lower rCBF in the medial, but not lateral, OFC relative to sex-matched healthy controls after placebo infusion (P<0.01). Male cocaine-dependent subjects also showed decreased rCBF (P<0.01) in the bilateral anterolateral temporal cortex and anterior cingulate, whereas decreased rCBF was observed in female cocaine-dependent subjects in the bilateral superior frontal gyri. Large and diffuse areas of increased rCBF were observed after placebo infusion in cocaine-dependent men, but not in women, relative to sex-matched healthy controls.
CONCLUSIONS: rCBF appears to be reduced in the bilateral OFC in cocaine-dependent men and in the medial OFC in cocaine-dependent women. Sex differences in the medial and lateral OFC rCBF may be relevant to understanding relapse characteristics differentiating men and women addicted to cocaine.
Bryon Adinoff; Mark J Williams; Susan E Best; Thomas S Harris; Patricia Chandler; Michael D Devous
Related Documents :
17949394 - Effects of cigarette smoking and family history of alcoholism on sweet taste perception...
6744784 - Nicotine and carbon monoxide intake from high- and low-yield cigarettes.
3829584 - Influence of tobacco abstinence on the disposition kinetics and effects of nicotine.
15113294 - Interobserver perceptual analysis of smokers voice.
8482594 - Respiratory function in greenhouse workers.
16754924 - Psychosocial factors and coronary calcium in adults without clinical cardiovascular dis...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Gender medicine     Volume:  3     ISSN:  1550-8579     ISO Abbreviation:  Gend Med     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-11-03     Completed Date:  2007-01-09     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  101225178     Medline TA:  Gend Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  206-22     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Flow Velocity / physiology
Cerebrovascular Circulation / physiology*
Cocaine-Related Disorders / physiopathology*,  radionuclide imaging
Frontal Lobe / blood supply*,  physiopathology,  radionuclide imaging
Middle Aged
Occipital Lobe / blood supply*,  physiopathology,  radionuclide imaging
Severity of Illness Index
Sex Factors
Tomography, Emission-Computed, Single-Photon
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gender differences in correlations among cardiovascular risk factors.
Next Document:  Dissimilarity in gene expression profiles of lung adenocarcinoma in Japanese men and women.