Document Detail


Sex differences in leukocyte invasion in injured murine skeletal muscle.
MedLine Citation:
PMID:  10344704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The three aims of this study were to describe the time course of leukocyte invasion in injured soleus muscles of male and female mice, to determine if differential subsets of leukocytes accumulate in intramyofiber and interstitial sites, and to determine if significant sex differences exist in invading leukocyte concentrations. Fifty sexually mature C57BL/6J mice (aged 11-12 weeks) underwent unilateral hindlimb muscle injury induced by lengthening contractions. This procedure models the muscle injury that can occur through strenuous exercise or overuse in humans. After 1, 3, 5, or 7 days of recovery, the injured and contralateral, uninjured solei were dissected and prepared for morphologic analysis. We found that leukocytes had invaded injured myofibers at 1-day postinjury for both sexes. Different subsets of leukocytes accumulated within damaged myofibers and the interstitium. Significantly fewer myofibers were invaded by acid phosphatase-positive leukocytes in females. Interstitial ER-BMDM1 leukocyte concentrations peaked in females at 7 days postinjury in comparison to 5 days postinjury in males. These findings expand nursing's knowledge base regarding the potential effect of gender on recovery from acute muscle injury.
Authors:
B St Pierre Schneider; L A Correia; J G Cannon
Related Documents :
11922624 - Skeletal muscle injury induces hepatocyte growth factor expression in spleen.
2429904 - The anatomy and physiology of the peripheral nerve.
20871484 - Comparison of single versus double nerve transfers for elbow flexion after brachial ple...
7359604 - Closed injuries of the pectoralis major muscle.
5765854 - Relationship between cortisone and muscle work in determining muscle size.
14748544 - Contraction-induced oxidants as mediators of adaptation and damage in skeletal muscle.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research in nursing & health     Volume:  22     ISSN:  0160-6891     ISO Abbreviation:  Res Nurs Health     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806136     Medline TA:  Res Nurs Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM; N    
Affiliation:
Department of Kinesiology, Noll Physiological Research Center, Pennsylvania State University, University Park 16802-6900, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Electric Stimulation / methods
Female
Hindlimb
Immunohistochemistry
Leukocytes / cytology*,  enzymology
Male
Mice
Mice, Inbred C57BL
Muscle Fibers, Skeletal / cytology,  enzymology
Muscle, Skeletal / cytology*,  enzymology,  injuries*
Sex Characteristics*
Tibial Nerve / physiology
Time Factors
Grant Support
ID/Acronym/Agency:
AR39595/AR/NIAMS NIH HHS; NR07097/NR/NINR NIH HHS; RR10732/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Testing a theory for health-related quality of life in cancer patients: a structural equation approa...
Next Document:  The effects of perceived and preferred control on nurses' job satisfaction in long term care environ...