Document Detail

Sex differences in leukocyte invasion in injured murine skeletal muscle.
MedLine Citation:
PMID:  10344704     Owner:  NLM     Status:  MEDLINE    
The three aims of this study were to describe the time course of leukocyte invasion in injured soleus muscles of male and female mice, to determine if differential subsets of leukocytes accumulate in intramyofiber and interstitial sites, and to determine if significant sex differences exist in invading leukocyte concentrations. Fifty sexually mature C57BL/6J mice (aged 11-12 weeks) underwent unilateral hindlimb muscle injury induced by lengthening contractions. This procedure models the muscle injury that can occur through strenuous exercise or overuse in humans. After 1, 3, 5, or 7 days of recovery, the injured and contralateral, uninjured solei were dissected and prepared for morphologic analysis. We found that leukocytes had invaded injured myofibers at 1-day postinjury for both sexes. Different subsets of leukocytes accumulated within damaged myofibers and the interstitium. Significantly fewer myofibers were invaded by acid phosphatase-positive leukocytes in females. Interstitial ER-BMDM1 leukocyte concentrations peaked in females at 7 days postinjury in comparison to 5 days postinjury in males. These findings expand nursing's knowledge base regarding the potential effect of gender on recovery from acute muscle injury.
B St Pierre Schneider; L A Correia; J G Cannon
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Research in nursing & health     Volume:  22     ISSN:  0160-6891     ISO Abbreviation:  Res Nurs Health     Publication Date:  1999 Jun 
Date Detail:
Created Date:  1999-06-10     Completed Date:  1999-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806136     Medline TA:  Res Nurs Health     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM; N    
Department of Kinesiology, Noll Physiological Research Center, Pennsylvania State University, University Park 16802-6900, USA.
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MeSH Terms
Cell Movement
Electric Stimulation / methods
Leukocytes / cytology*,  enzymology
Mice, Inbred C57BL
Muscle Fibers, Skeletal / cytology,  enzymology
Muscle, Skeletal / cytology*,  enzymology,  injuries*
Sex Characteristics*
Tibial Nerve / physiology
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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