Document Detail


Sex differences in the features of coronary artery disease of patients undergoing coronary angiography.
MedLine Citation:
PMID:  8689538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine sex differences in the features of coronary artery disease (CAD) of patients who have undergone coronary angiography. DESIGN: Retrospective study which reviewed clinical and angiographic results from eligible patients who underwent coronary angiography under one cardiologist during a consecutive period. SETTING: Tertiary referral women's health centre. PATIENTS: 515 patients (167 women, 348 men) who underwent coronary angiography for suspected CAD, excluding those with previously known primary valvular disease, valvular replacement, congenital heart disease, nonischemic cardiomyopathy, history of cocaine-induced myocardial ischemia or infarction, and those who had previously undergone coronary angiography, coronary artery bypass graft or percutaneous transluminal coronary angioplasty. MAIN RESULTS: Overall, females and males presented at similar ages and with similar prevalences of smoking, diabetes, hypertension, and family histories of premature CAD, albeit women were less likely than men to have a prior history of myocardial infarction. The observed age difference between females and males with coronary disease was less than expected (3.3 +/- 2.3 years, 95% confidence limits). At angiography, women were three times more likely than men to have normal coronary arteries. Yet, in patients found to have coronary disease, there was no sex difference in either the severity or the distribution of the disease. Women were twice as likely as men to have normal left ventricular function on catheterization. However, when all cases of normal angiograms were excluded, multivariate logistic regression analysis showed that, after controlling for other important confounding factors, females were as likely as males to have significant CAD and left ventricular dysfunction on angiography. CONCLUSIONS: Women can develop serious ischemic heart disease that is similar to that in men and at a relatively younger age than previously described. The vulnerability to ischemic heart disease in nonelderly women needs to be emphasized.
Authors:
P Jong; S Mohammed; L Sternberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  12     ISSN:  0828-282X     ISO Abbreviation:  Can J Cardiol     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-08-26     Completed Date:  1996-08-26     Revised Date:  2008-04-09    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  671-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Toronto, Ontario.
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Angiography
Coronary Disease / physiopathology*,  radiography
Female
Humans
Male
Middle Aged
Odds Ratio
Retrospective Studies
Sex Characteristics*
Ventricular Function, Left
Comments/Corrections
Erratum In:
Can J Cardiol 1996 Sep;12(9):781

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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