Document Detail

Sex differences in the endothelial function of untreated hypertension.
MedLine Citation:
PMID:  22458744     Owner:  NLM     Status:  MEDLINE    
Vascular endothelial dysfunction is associated with increased risk for adverse cardiovascular (CV) events. However, less is known about sex differences in the endothelial function of untreated hypertensive individuals. The purpose of this study was to assess endothelial function in women and men with untreated hypertension. Ninety participants (35 women, 55 men), aged 40 to 60 years (mean age, 46.1±8.2 years), with untreated stage 1 hypertension (systolic blood pressure 140-159 mm Hg and/or diastolic blood pressure 90-99 mm Hg) underwent brachial artery endothelial-dependent flow-mediated dilation and endothelial-independent glyceryl trinitrate dilation. Women had a smaller flow-mediated dilation response than men (adjusted mean±standard error of the mean [SEM]; 1.8±0.6% vs 3.9±0.4%, P=.036), adjusting for baseline arterial diameter (P=.004), age (P=.596), ethnicity (P=.496), log shear stress ratio (P<.001), body mass index (P=.009), 24-hour diastolic blood pressure (P=.169), high-density lipoprotein (P=.225), log creatinine (P=.927), and log physical activity (P=.682). Glyceryl trinitrate dilation did not differ by sex in adjusted models. Women between the ages of 40 and 60 years with untreated stage 1 hypertension exhibited a greater impairment of endothelial function compared with their male counterparts. These findings raise the possibility that female sex may impart a greater risk of CV events in patients with untreated stage 1 hypertension potentially due to poorer endothelial function.
Faye S Routledge; Alan L Hinderliter; James A Blumenthal; Andrew Sherwood
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-03-05
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  14     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-30     Completed Date:  2012-08-07     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-35     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
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MeSH Terms
Analysis of Variance
Cardiovascular Diseases / epidemiology,  etiology
Endothelium, Vascular / physiopathology*
Hypertension / drug therapy,  epidemiology,  physiopathology*
Middle Aged
Risk Factors
Sex Factors
Statistics as Topic
Statistics, Nonparametric
United States / epidemiology
Grant Support
HL072390/HL/NHLBI NIH HHS; M01-RR-30/RR/NCRR NIH HHS; R01 HL072390-01/HL/NHLBI NIH HHS; R01 HL072390-02/HL/NHLBI NIH HHS; R01 HL072390-03/HL/NHLBI NIH HHS; R01 HL072390-04/HL/NHLBI NIH HHS
Comment In:
J Clin Hypertens (Greenwich). 2012 Aug;14(8):493-5   [PMID:  22863155 ]

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