| Sex differences in the endocrine system in response to protein intake early in life. | |
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MedLine Citation:
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PMID: 22089446 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Nutritional factors during a sensitive period can influence child development in a sex-related manner. OBJECTIVE: Our aim was to investigate whether sex modulates the responses of relevant biochemical parameters and growth to different protein intakes early in life. DESIGN: In a randomized controlled trial, formula-fed infants were assigned to receive formula with higher protein (HP) or lower protein (LP) content. The main outcome measures were insulin-like growth factor (IGF)-1 axis parameters, weight, length, BMI, leptin, and C-peptide/creatinine ratio at 6 mo of age. Dietary intake during the first 6 mo of life was also assessed. RESULTS: The IGF-1 axis response to HP feeding was modulated by sex. Total and free IGF-1 and IGF binding protein 3 concentrations were higher in girls than in boys. Compared with the LP diet, the HP diet was associated with higher IGF-1 and lower IGF binding protein 2 secretion. The response to this HP content formula tended to be stronger in girls than in boys. The HP diet was associated with a higher C-peptide/creatinine ratio. The leptin concentration was higher in girls than in boys and was correlated to the IGF-1 axis parameters. No interaction between sex and nutritional intervention was shown on growth. CONCLUSIONS: Our findings show that the endocrine response to a high protein diet early in life may be modulated by sex. The IGF-1 axis of female infants shows a stronger response to the nutritional intervention than does that of male infants, but there is no enhanced effect on growth. This trial was registered at clinicaltrials.gov as NCT00338689. |
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Authors:
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Ricardo Closa-Monasterolo; Natàlia Ferré; Verónica Luque; Marta Zaragoza-Jordana; Veit Grote; Martina Weber; Berthold Koletzko; Piotr Socha; Dariusz Gruszfeld; Roman Janas; Annick Xhonneux; Elena Dain; Silvia Scaglioni; Joaquin Escribano; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: - ISSN: 1938-3207 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From Universitat Rovira i Virgili, Tarragona, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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