Document Detail

Sex differences in development of fetal rat lung. I. Autoradiographic and biochemical studies.
MedLine Citation:
PMID:  6708455     Owner:  NLM     Status:  MEDLINE    
Sex-related differences in lung maturity have been associated with lower surfactant production by the male fetus in late gestation, but the possibility that differences in lung growth occur between male and female lungs has not been examined in detail. Using rat littermates grouped according to sex from day 17 to 22 of gestation, we have now correlated proliferation of the various lung cell types with biochemical indices of cell function. Although the overall 3H-thymidine-labeling index in the lung decreases sharply in all animals approaching full term, the proportion of epithelial cell labeling increases from 30% at day 17 to 47% at day 20. During this period there are significantly more labeled epithelial cells in females than in male littermates. At the conclusion of this phase of epithelial proliferation, day 20 of gestation, the level of disaturated phosphatidylcholine increases sharply and is significantly greater in female lungs. Subsequently, the male fetus appears to "catch up," and sex-related differences in cell proliferation and surfactant levels are eliminated. The results suggest that differences in lung structure between males and females predate surfactant differences and are first observed during a period of epithelial proliferation. Completion of this phase results in earlier differentiation and surfactant synthesis in the female fetus.
I Y Adamson; G M King
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory investigation; a journal of technical methods and pathology     Volume:  50     ISSN:  0023-6837     ISO Abbreviation:  Lab. Invest.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-05-11     Completed Date:  1984-05-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376617     Medline TA:  Lab Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  456-60     Citation Subset:  IM    
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MeSH Terms
Cell Division
DNA / metabolism
Epithelial Cells
Fetal Proteins / metabolism
Fetus / physiology*
Hydroxyproline / metabolism
Lung / cytology*,  growth & development,  physiology
Organ Size
Pregnancy, Animal*
Rats, Inbred Strains
Sex Characteristics*
Grant Support
Reg. No./Substance:
0/Fetal Proteins; 51-35-4/Hydroxyproline; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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