Document Detail


Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic.
MedLine Citation:
PMID:  17706956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To find whether the control of betaine metabolism differs between male and female patients and identify the effects of insulin and other hormones. DESIGN AND METHODS: Data from non-diabetic lipid clinic patients (82 female symbol and 76 male symbol) were re-analyzed by sex. Data on insulin, thyroid hormones and leptin were included in models to identify factors affecting the circulation and excretion of betaine and its metabolites. RESULTS: Different factors influenced plasma concentrations and urinary excretion of betaine, dimethylglycine and homocysteine in males and females. In males, apolipoprotein B (negative), thyroid stimulating hormone (positive) and insulin (negative) predicted circulating betaine, consistent with betaine-homocysteine methyltransferase mediated control. In females, insulin positively predicted plasma dimethylglycine. Urinary betaine excretion positively predicted circulating homocysteine in males (p<0.001), whereas dimethylglycine excretion (also indicating betaine loss) was a stronger positive predictor (p<0.001) in females. Carnitine affected betaine homeostasis. CONCLUSIONS: Betaine metabolism is under endocrine control, and studies should use sex stratified groups.
Authors:
Michael Lever; Wendy Atkinson; Peter M George; Stephen T Chambers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-17
Journal Detail:
Title:  Clinical biochemistry     Volume:  40     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1225-31     Citation Subset:  IM    
Affiliation:
Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand. michael.lever@chmeds.ac.nz
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MeSH Terms
Descriptor/Qualifier:
Adult
Betaine / blood*,  urine*
Betaine-Homocysteine S-Methyltransferase / metabolism
Carnitine / blood,  urine
Female
Homocysteine / blood
Humans
Lipid Metabolism Disorders / blood*,  urine*
Male
Middle Aged
Sarcosine / analogs & derivatives,  blood,  urine
Sex Factors
Thyroid Hormones / blood
Chemical
Reg. No./Substance:
0/Thyroid Hormones; 107-43-7/Betaine; 107-97-1/Sarcosine; 1118-68-9/dimethylglycine; 454-28-4/Homocysteine; 541-15-1/Carnitine; EC 2.1.1.5/Betaine-Homocysteine S-Methyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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