| Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. | |
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MedLine Citation:
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PMID: 17706956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To find whether the control of betaine metabolism differs between male and female patients and identify the effects of insulin and other hormones. DESIGN AND METHODS: Data from non-diabetic lipid clinic patients (82 female symbol and 76 male symbol) were re-analyzed by sex. Data on insulin, thyroid hormones and leptin were included in models to identify factors affecting the circulation and excretion of betaine and its metabolites. RESULTS: Different factors influenced plasma concentrations and urinary excretion of betaine, dimethylglycine and homocysteine in males and females. In males, apolipoprotein B (negative), thyroid stimulating hormone (positive) and insulin (negative) predicted circulating betaine, consistent with betaine-homocysteine methyltransferase mediated control. In females, insulin positively predicted plasma dimethylglycine. Urinary betaine excretion positively predicted circulating homocysteine in males (p<0.001), whereas dimethylglycine excretion (also indicating betaine loss) was a stronger positive predictor (p<0.001) in females. Carnitine affected betaine homeostasis. CONCLUSIONS: Betaine metabolism is under endocrine control, and studies should use sex stratified groups. |
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Authors:
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Michael Lever; Wendy Atkinson; Peter M George; Stephen T Chambers |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-17 |
Journal Detail:
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Title: Clinical biochemistry Volume: 40 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2008-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1225-31 Citation Subset: IM |
Affiliation:
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Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand. michael.lever@chmeds.ac.nz |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Betaine / blood*, urine* Betaine-Homocysteine S-Methyltransferase / metabolism Carnitine / blood, urine Female Homocysteine / blood Humans Lipid Metabolism Disorders / blood*, urine* Male Middle Aged Sarcosine / analogs & derivatives, blood, urine Sex Factors Thyroid Hormones / blood |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones; 107-43-7/Betaine; 107-97-1/Sarcosine; 1118-68-9/dimethylglycine; 454-28-4/Homocysteine; 541-15-1/Carnitine; EC 2.1.1.5/Betaine-Homocysteine S-Methyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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