Document Detail

Sex differences in control of blood pressure: role of oxidative stress in hypertension in females.
MedLine Citation:
PMID:  18567715     Owner:  NLM     Status:  MEDLINE    
In general, blood pressure is higher in normotensive men than in age-matched women, and the prevalence of hypertension in men is also higher until after menopause, when the prevalence of hypertension increases for women. It is likely then that the mechanisms by which blood pressure increases in men and women with aging may be different. Although clinical trials to reduce blood pressure with antioxidants have typically not been successful in human cohorts, studies in male rats suggest that oxidative stress plays an important role in mediating hypertension. The exact mechanisms by which oxidative stress increases blood pressure have not been completely elucidated. There may be several reasons for the discrepancies between clinical and animal studies. In this review, the data obtained in selected clinical and animal studies are discussed, and the hypothesis is put forward that oxidative stress may not be as important in mediating hypertension in females as has been shown previously in male rats. Furthermore, it is likely that differences in genetics, age, length of time with hypertension, endothelial dysfunction, and sex are all factored in to modulate the responses to antioxidants in humans. As such, future clinical trials should be designed and powered to evaluate the effects of oxidative stress on blood pressure separately in men and women.
Arnaldo Lopez-Ruiz; Julio Sartori-Valinotti; Licy L Yanes; Radu Iliescu; Jane F Reckelhoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2008-06-20
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  295     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-08     Completed Date:  2008-09-25     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H466-74     Citation Subset:  IM    
Dept. of Physiology and Biophysics, Univ. of Mississippi Medical Center, 2500 North State St., Jackson, MS 39216-4505, USA.
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MeSH Terms
Age Factors
Antihypertensive Agents / therapeutic use
Antioxidants / therapeutic use
Biological Markers / metabolism
Blood Pressure* / drug effects
Disease Models, Animal
Estradiol / metabolism
Hypertension / drug therapy,  metabolism,  physiopathology*
Kidney / enzymology
Oxidative Stress* / drug effects
Sex Factors
Grant Support
Reg. No./Substance:
0/Antihypertensive Agents; 0/Antioxidants; 0/Biological Markers; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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