Document Detail

Sex differences in calf muscle hemoglobin oxygen saturation in patients with intermittent claudication.
MedLine Citation:
PMID:  19223136     Owner:  NLM     Status:  MEDLINE    
PURPOSES: We tested the hypotheses that women have greater impairment in calf muscle hemoglobin oxygen saturation (StO(2)) in response to exercise than men, and that the sex-related difference in calf muscle StO(2) would partially explain the shorter claudication distances of women.
METHODS: The study comprised 27 men and 24 women with peripheral arterial disease limited by intermittent claudication. Patients were characterized on calf muscle StO(2) before, during, and after a graded treadmill test, as well as on demographic and cardiovascular risk factors, ankle-brachial index (ABI), ischemic window, initial claudication distance (ICD), and absolute claudication distance (ACD).
RESULTS: Women had a 45% lower ACD than men (296 +/- 268 m vs 539 +/- 288 m; P = .001) during the treadmill test. Calf muscle StO(2) declined more rapidly during exercise in women than in men; the time to reach minimum StO(2) occurred 54% sooner in women (226 +/- 241 vs 491 +/- 426 seconds; P = .010). The recovery time for calf muscle StO(2) to reach the resting value after treadmill exercise was prolonged in women (383 +/- 365 vs 201 +/- 206 seconds; P = .036). Predictors of ACD included the time from start of exercise to minimum calf muscle StO(2), the average rate of decline in StO(2) from rest to minimum StO(2) value, the recovery half-time of StO(2), and ABI (R(2) = 0.70; P < .001). The ACD of women remained lower after adjusting for ABI (mean difference, 209 m; P = .003), but was no longer significantly lower (mean difference, 72 m; P = .132) after further adjustment for the StO(2) variables for the three calf muscles.
CONCLUSION: In patients limited by intermittent claudication, women have lower ACD and greater impairment in calf muscle StO(2) during and after exercise than men, the exercise-mediated changes in calf muscle StO(2) are predictive of ACD, and women have similar ACD as men after adjusting for calf StO(2) and ABI measures.
Andrew W Gardner; Donald E Parker; Polly S Montgomery; Steve M Blevins; Raha Nael; Azhar Afaq
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-02-15
Journal Detail:
Title:  Journal of vascular surgery     Volume:  50     ISSN:  1097-6809     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-07-09     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
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MeSH Terms
Exercise / physiology
Exercise Test
Hemoglobins / chemistry*,  metabolism
Intermittent Claudication / metabolism*
Middle Aged
Muscle, Skeletal / metabolism*
Oxygen / analysis*,  metabolism
Peripheral Vascular Diseases
Sex Factors
Grant Support
M01 RR014467-01A1/RR/NCRR NIH HHS; M01-RR-14467/RR/NCRR NIH HHS; R01 AG024296/AG/NIA NIH HHS; R01 AG024296-01A2/AG/NIA NIH HHS; R01-AG-24296/AG/NIA NIH HHS
Reg. No./Substance:
0/Hemoglobins; S88TT14065/Oxygen

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