| Sex differences in the benefits of rehabilitative training during adolescence following neonatal hypoxia-ischemia in rats. | |
| | |
MedLine Citation:
|
PMID: 20833167 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Much effort and many resources are being devoted to rehabilitative programs for children with disabilities caused by neonatal hypoxic-ischemic encephalopathy without clear evidence of the efficacy of such programs. We recently reported that rehabilitative training tasks during adolescence improve spatial learning impairment following neonatal hypoxic-ischemic injury in rats without histological improvement. In the present study we focused on sex differences. Wister rat pups were exposed to a unilateral hypoxic-ischemic insult at 7 days of age. Six weeks after hypoxia-ischemia, rehabilitative training tasks were started. The tasks consisted of the plus maze, the eight-arm radial maze, and the choice reaction time task. Sixteen weeks after the insult, the water maze task was performed to evaluate spatial learning ability. Afterwards, we morphologically examined brain injury. Our rehabilitative training significantly improved swimming time and length in females (P<0.01) but not in males. Likewise, the training ameliorated infarct areas in the injured cerebral hemisphere in females but not in males (P<0.01). These results suggest that it may be important to develop and evaluate cognitive rehabilitation programs for children with brain injury on the basis of gender. |
| | |
Authors:
|
Masahiro Tsuji; Naoya Aoo; Kazuhiro Harada; Yuya Sakamoto; Yoshiharu Akitake; Keiichi Irie; Kenichi Mishima; Tomoaki Ikeda; Michihiro Fujiwara |
Related Documents
:
|
7262847 - Predicting the community performance of vocational rehabilitation clients. 6383977 - How to select a satisfying typing program for paternity testing. 10315477 - Strategies for developing a cost-effective pulmonary rehabilitation program. 8364597 - Rehabilitation of the shoulder following rotator cuff injury or surgery. 21330807 - Evaluating an automated haptic simulator designed for veterinary students to learn bovi... 16918737 - Assessing physicians' orientation toward lifelong learning. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
|
Title: Experimental neurology Volume: 226 ISSN: 1090-2430 ISO Abbreviation: Exp. Neurol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-10-26 Completed Date: 2010-11-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370712 Medline TA: Exp Neurol Country: United States |
Other Details:
|
Languages: eng Pagination: 285-92 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Regenerative Medicine and Tissue Engineering, National Cerebral and Cardiovascular Center Research Institute, 5-7-1, Fujishiro-dai, Suita, Osaka, 565-8565, Japan. mtsuji@ri.ncvc.go.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Animals, Newborn Behavior, Animal Disease Models, Animal Female Hypoxia-Ischemia, Brain / pathology, physiopathology, rehabilitation* Male Maze Learning / physiology Random Allocation Rats Rats, Wistar Sex Characteristics* Swimming / psychology Teaching / methods* Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gold nanoparticles downregulate VEGF-and IL-1β-induced cell proliferation through Src kinase in Ret...
Next Document: Toxoplasma gondii: Inhibitory activity and encystation effect of securinine and pyrrolidine derivati...