Document Detail

Sex differences in antidepressant-like effect of chronic repetitive transcranial magnetic stimulation in rats.
MedLine Citation:
PMID:  17291659     Owner:  NLM     Status:  MEDLINE    
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurophysiological technique. Pre-clinical and clinical studies supported that rTMS might have antidepressant effects. However, whether antidepressant effect of chronic rTMS is gender-dependent is still unknown. In this study, male and female Wistar rats received 10-day rTMS (4 trains of 15 Hz; 200 stimuli/day; 1.0 T) or control condition, and then were subjected to the forced-swim test (FST). We found that female rats consistently showed higher activity levels than males in FST and revealed the significant effects of gender and rTMS as well as the interaction of gender and rTMS. The result suggested the antidepressant-like effects of chronic rTMS on behavioral components in FST are gender-dependent. The gender discrepancy related to rTMS should not be neglected in antidepressant treatment of rTMS.
Yuye Yang; Wei Li; Bin Zhu; Yanyou Liu; Bo Yang; Hongxing Wang; Zhengrong Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-16
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  31     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  735-40     Citation Subset:  IM    
Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan, People's Republic of China.
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MeSH Terms
Analysis of Variance
Behavior, Animal / physiology*,  radiation effects
Brain / radiation effects
Immobility Response, Tonic / physiology,  radiation effects
Motor Activity / physiology,  radiation effects
Rats, Wistar
Reaction Time / physiology,  radiation effects
Sex Characteristics*
Swimming / psychology
Transcranial Magnetic Stimulation*

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