| Sex differences in amino acid release from rostral trigeminal subnucleus caudalis after acute injury to the TMJ region. | |
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MedLine Citation:
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PMID: 12098620 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neurological basis for painful temporomandibular disorders (TMD) and the higher prevalence of TMD pain in women than men is not known. To better define the circuitry and neurochemical mechanisms in the lower brainstem associated with noxious sensory inputs from the temporomandibular joint (TMJ) region a microdialysis method was used to measure the release of amino acid transmitters from the ventral trigeminal subnucleus interpolaris/caudalis transition region (Vi/Vc-vl). The irritant chemical, mustard oil, was injected into the TMJ region (TMJ-MO) under barbiturate anesthesia in males and normal cycling female rats. Males displayed significant increases in glutamate, serine, and glycine within 15 min after TMJ-MO and increases in citrulline occurred after a delay of 15-30 min. TMJ-MO did not enhance amino acid release in diestrus or proestrus females. GABA release was not affected by TMJ-MO in males or females. Pretreatment with morphine (3 mg/kg, i.v.) prevented the increase in amino acid release seen after TMJ-MO in males. Amino acid release at the Vi/Vc-vl transition region evoked by TMJ-MO also was prevented by prior microinjection of the GABA(A) receptor agonist, muscimol, into the most caudal portion of Vc suggesting this region acted as a critical relay for nociceptive inputs from the TMJ region. These results suggest that glutamatergic mechanisms acting at the Vi/Vc-vl transition region contribute to processing of nociceptive signals that arise from the TMJ region. These results also are consistent with the hypothesis that central neural mechanisms that integrate nociceptive inputs from deep craniofacial tissues are different in males and females. |
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Authors:
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D A Bereiter; S Shen; A P Benetti |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pain Volume: 98 ISSN: 0304-3959 ISO Abbreviation: Pain Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-07-05 Completed Date: 2002-09-06 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: Netherlands |
Other Details:
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Languages: eng Pagination: 89-99 Citation Subset: IM |
Affiliation:
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Department of Surgery, Brown Medical School, Rhode Island Hospital, 222 Nursing Arts Bldg., Providence, RI 02903, USA. dbereiter@lifespan.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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metabolism* Animals Female GABA Agonists / pharmacology Glutamic Acid / metabolism Glycine / pharmacology Irritants / pharmacology* Male Muscimol / pharmacology Mustard Plant Nerve Block Neurotransmitter Agents / metabolism Plant Extracts / pharmacology* Plant Oils Rats Rats, Sprague-Dawley Sex Characteristics* Temporomandibular Joint / drug effects* Trigeminal Caudal Nucleus / drug effects, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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DE 12758/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/GABA Agonists; 0/Irritants; 0/Neurotransmitter Agents; 0/Plant Extracts; 0/Plant Oils; 2763-96-4/Muscimol; 56-40-6/Glycine; 56-86-0/Glutamic Acid; 8007-40-7/mustard oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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